Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
iroIron oxidase; Identified by similarity to SP:P50500; match to protein family HMM TIGR01409. (106 aa)    
Predicted Functional Partners:
petC-2
Ubiquinol--cytochrome c reductase, cytochrome c1 subunit; Identified by match to protein family HMM PF02167.
     
 0.757
cyc2
Cytochrome c; Identified by similarity to GB:CAA07031.1.
      
 0.724
cycA-2
Cytochrome c4; Identified by match to protein family HMM PF00034.
     
 0.570
petB-2
Ubiquinol--cytochrome c reductase, cytochrome b subunit; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.
       0.497
purA
Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
      
 0.491
AFE_2733
Hypothetical protein; Identified by glimmer; putative.
       0.459
cyc1
Cytochrome c552; Identified by similarity to SP:P74917; match to protein family HMM PF00034.
      
 0.446
petA-2
Ubiquinol--cytochrome c reductase, iron-sulfur subunit; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.
       0.445
cycA-1
Cytochrome c4; Identified by match to protein family HMM PF00034.
      
 0.443
feoB
Ferrous iron transport protein B; Probable transporter of a GTP-driven Fe(2+) uptake system. Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
      
 0.440
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
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