Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AFE_2749Conserved hypothetical protein; Identified by similarity to PIR:D75566; match to protein family HMM PF08754. (110 aa)    
Predicted Functional Partners:
rpoH
RNA polymerase sigma-32 factor; Identified by similarity to SP:P00580; match to protein family HMM PF04542; match to protein family HMM PF04545; match to protein family HMM TIGR02392; match to protein family HMM TIGR02937; Belongs to the sigma-70 factor family.
       0.805
htpG
Heat shock protein HtpG; Molecular chaperone. Has ATPase activity.
   
   0.585
ftsY
Signal recognition particle-docking protein FtsY; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.
  
    0.543
AFE_3220
Hypothetical protein; Identified by glimmer; putative.
  
     0.533
AFE_1106
Transposon, transposase; Adjacent to a gene for resolvase; identified by match to protein family HMM TIGR01766.
  
     0.499
AFE_2751
Cell division protein FtsX, putative; Part of the ABC transporter FtsEX involved in cellular division; Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.
       0.493
ftsE
Cell division ATP-binding protein FtsE; Part of the ABC transporter FtsEX involved in cellular division.
       0.493
AFE_3221
Magnesium and cobalt transport protein, putative; Identified by match to protein family HMM PF01544.
  
     0.493
AFE_1695
Conjugal transfer protein; Identified by similarity to SP:P54915; match to protein family HMM PF03524.
  
     0.491
AFE_1642
Conjugal transfer protein trbL, putative; Identified by similarity to GB:AAN33564.1; match to protein family HMM TIGR02783.
  
     0.442
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
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