Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AFE_2775Identified by match to protein family HMM PF01925. (261 aa)    
Predicted Functional Partners:
AFE_2776
Benzoylformate decarboxylase; Identified by similarity to SP:P20906; match to protein family HMM PF00205; match to protein family HMM PF02775; match to protein family HMM PF02776; Belongs to the TPP enzyme family.
 
     0.637
AFE_2640
Hypothetical protein; Identified by glimmer; putative.
 
     0.538
AFE_2235
Hypothetical protein; Identified by glimmer; putative.
  
     0.514
ppa
Inorganic pyrophosphatase; Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
  
   
 0.512
AFE_1136
Membrane protein, DedA family; Identified by similarity to PIR:AH3439; match to protein family HMM PF09335.
  
   
 0.510
AFE_0764
Membrane protein, putative; Identified by similarity to GB:AAQ58180.1; match to protein family HMM PF01925.
  
     0.505
groES
Chaperonin, 10 kDa; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.
   
  
 0.454
mreB
Rod shape-determining protein MreB; Identified by similarity to SP:P13519; match to protein family HMM PF06723; match to protein family HMM TIGR00904.
  
  
 0.452
arsH
Arsenical resistance protein ArsH; Has NADPH-dependent FMN reductase activity and high NADPH- dependent ferric reductase activity with highest activity for Fe(3+) as substrate. No activity with NADH, iron trichloride, Cu(2+) or Ag(+). May be involved in cytosolic ferric iron assimilation as an NADPH- dependent ferric reductase in vivo; Belongs to the ArsH family.
      
 0.446
arsR
Transcriptional regulator, ArsR; Identified by match to protein family HMM PF01022.
     
 0.442
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
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