Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AFE_2799Transcriptional regulator, Ada family/DNA-3-methyladenine glycosylase II; Identified by similarity to SP:P04395; match to protein family HMM PF00165; match to protein family HMM PF00730; match to protein family HMM PF02805; match to protein family HMM PF06029. (496 aa)    
Predicted Functional Partners:
AFE_1848
Base excision repair protein, HhH-GPD family; Identified by similarity to SP:P37878; match to protein family HMM PF00730.
 
  
0.951
ogt-1
methylated-DNA--protein-cysteine methyltransferase; Identified by similarity to SP:P09168; match to protein family HMM PF01035; match to protein family HMM TIGR00589.
  
 0.919
AFE_2800
Identified by match to protein family HMM PF00903.
     
 0.846
ogt-2
methylated-DNA--protein-cysteine methyltransferase; Identified by similarity to SP:P09168; match to protein family HMM PF01035; match to protein family HMM PF02870; match to protein family HMM TIGR00589.
  
 0.819
AFE_2100
Hypothetical protein; Identified by glimmer; putative.
      
 0.722
xth-2
Exodeoxyribonuclease III; Identified by match to protein family HMM PF03372; match to protein family HMM TIGR00195; match to protein family HMM TIGR00633.
   
 0.703
xth-1
Exodeoxyribonuclease III; Identified by match to protein family HMM PF03372; match to protein family HMM TIGR00195; match to protein family HMM TIGR00633.
   
 0.703
recA
recA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 
 0.628
AFE_1751
umuC protein; Identified by match to protein family HMM PF00817.
  
 
 0.602
AFE_1870
Conserved hypothetical protein; Identified by similarity to GB:AAM40399.1.
  
 
 0.602
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
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