Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AFE_2800Identified by match to protein family HMM PF00903. (132 aa)    
Predicted Functional Partners:
AFE_2799
Transcriptional regulator, Ada family/DNA-3-methyladenine glycosylase II; Identified by similarity to SP:P04395; match to protein family HMM PF00165; match to protein family HMM PF00730; match to protein family HMM PF02805; match to protein family HMM PF06029.
     
 0.846
AFE_2801
Oxidoreductase, short-chain dehydrogenase/reductase family; Identified by match to protein family HMM PF00106; match to protein family HMM PF01370; match to protein family HMM PF08659.
  
   0.791
AFE_1848
Base excision repair protein, HhH-GPD family; Identified by similarity to SP:P37878; match to protein family HMM PF00730.
      
 0.723
AFE_2100
Hypothetical protein; Identified by glimmer; putative.
      
 0.722
AFE_3010
Polyketide synthase, type I, putative; Identified by similarity to GB:AAK26474.1; match to protein family HMM PF00106; match to protein family HMM PF00107; match to protein family HMM PF00109; match to protein family HMM PF00550; match to protein family HMM PF00698; match to protein family HMM PF02801; match to protein family HMM PF08240; match to protein family HMM PF08659.
  
 
 0.582
AFE_2802
Multidrug resistance protein, SMR family; Identified by match to protein family HMM PF00893.
  
    0.571
AFE_3079
Identified by match to protein family HMM PF00881.
  
  
 0.494
AFE_2803
FMN reductase, NADPH-dependent; Identified by match to protein family HMM PF03358.
  
  
 0.483
nuoD
NADH-quinone oxidoreductase, D subunit; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I 49 kDa subunit family.
  
    0.477
nifW
nifW protein, putative; May protect the nitrogenase Fe-Mo protein from oxidative damage; Belongs to the NifW family.
      
 0.464
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
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