STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AFE_2802Multidrug resistance protein, SMR family; Identified by match to protein family HMM PF00893. (109 aa)    
Predicted Functional Partners:
AFE_2803
FMN reductase, NADPH-dependent; Identified by match to protein family HMM PF03358.
       0.608
AFE_2804
Conserved hypothetical protein; Identified by similarity to GB:AAQ59281.1.
       0.608
AFE_2805
Conserved hypothetical protein; Identified by similarity to GB:CAD16379.1; match to protein family HMM PF07883.
       0.608
AFE_2806
Conserved hypothetical protein; Identified by similarity to PIR:B83761.
       0.595
AFE_2800
Identified by match to protein family HMM PF00903.
  
  
 0.579
AFE_2807
Transcriptional regulator, putative; Identified by match to protein family HMM PF04299.
       0.572
AFE_2801
Oxidoreductase, short-chain dehydrogenase/reductase family; Identified by match to protein family HMM PF00106; match to protein family HMM PF01370; match to protein family HMM PF08659.
       0.565
guaA
GMP synthase; Catalyzes the synthesis of GMP from XMP.
  
  
 0.445
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
     
 0.401
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.