Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AFE_2840Glycosyl hydrolase, family 57; Identified by match to protein family HMM PF03065; match to protein family HMM PF09095. (672 aa)    
Predicted Functional Partners:
glgC
Glucose-1-phosphate adenylyltransferase; Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc; Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
    
  0.979
glgB
1,4-alpha-glucan branching enzyme; Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position; Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
    
  0.958
glgA
Glycogen synthase; Synthesizes alpha-1,4-glucan chains using ADP-glucose.
  
 
  0.921
AFE_0527
Glycogen/starch/alpha-glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.
  
 
  0.913
AFE_1799
Identified by match to protein family HMM PF00343; match to protein family HMM TIGR02094.
  
 
  0.913
AFE_2224
Glycosyl hydrolase, family 15; Identified by match to protein family HMM PF00723; match to protein family HMM PF09137.
  
 
  0.910
cga
Glucan 1,4-alpha-glucosidase; Identified by match to protein family HMM PF00723; match to protein family HMM PF09137.
  
 
  0.910
galU
UTP-glucose-1-phosphate uridylyltransferase; Identified by similarity to SP:Q05852; match to protein family HMM PF00483; match to protein family HMM TIGR01099.
     
  0.900
AFE_2324
Phosphoglucomutase, putative; Identified by similarity to SP:P39671; match to protein family HMM PF00408; match to protein family HMM PF02878; match to protein family HMM PF02879; match to protein family HMM PF02880.
     
  0.900
AFE_2839
Glycosyl hydrolase, family 57; Identified by match to protein family HMM PF03065.
 
     0.864
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
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