Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Neighborhood
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
arsRTranscriptional regulator, ArsR; Identified by match to protein family HMM PF01022. (118 aa)    
Predicted Functional Partners:
arsC
Arsenate reductase; Identified by similarity to GB:AAF69239.1; match to protein family HMM PF01451; Belongs to the low molecular weight phosphotyrosine protein phosphatase family.
  
 0.990
arsB
Arsenical pump membrane protein; Identified by similarity to GB:AAF69238.1; match to protein family HMM PF02040; match to protein family HMM PF03600; match to protein family HMM TIGR00935.
 
  
 0.924
arsH
Arsenical resistance protein ArsH; Has NADPH-dependent FMN reductase activity and high NADPH- dependent ferric reductase activity with highest activity for Fe(3+) as substrate. No activity with NADH, iron trichloride, Cu(2+) or Ag(+). May be involved in cytosolic ferric iron assimilation as an NADPH- dependent ferric reductase in vivo; Belongs to the ArsH family.
     
 0.897
AFE_2421
Cd(II)/Pb(II)-responsive transcriptional regulator; Identified by match to protein family HMM PF00376; match to protein family HMM PF09278; match to protein family HMM TIGR02047.
      
 0.501
trxB
Thioredoxin-disulfide reductase; Identified by match to protein family HMM PF00070; match to protein family HMM PF07992; match to protein family HMM TIGR01292.
     
 0.480
pstB
Phosphate ABC transporter, ATP-binding protein; Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
     
 0.480
hisA
Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by similarity to SP:O35006; match to protein family HMM PF00977; match to protein family HMM TIGR00007.
      
 0.469
yghU
Glutathione S-transferase family protein YghU; Identified by similarity to SP:Q46845; match to protein family HMM PF00043; match to protein family HMM PF02798; Belongs to the GST superfamily.
     
 0.467
pstA
Phosphate ABC transporter, permease protein PstA; Identified by similarity to SP:P07654; match to protein family HMM PF00528; match to protein family HMM TIGR00974.
     
 0.461
merC
Mercuric resistance protein MerC; Identified by similarity to SP:P22905; match to protein family HMM PF03203.
      
 0.449
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
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