Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
arsCArsenate reductase; Identified by similarity to GB:AAF69239.1; match to protein family HMM PF01451; Belongs to the low molecular weight phosphotyrosine protein phosphatase family. (163 aa)    
Predicted Functional Partners:
arsR
Transcriptional regulator, ArsR; Identified by match to protein family HMM PF01022.
  
 0.990
arsH
Arsenical resistance protein ArsH; Has NADPH-dependent FMN reductase activity and high NADPH- dependent ferric reductase activity with highest activity for Fe(3+) as substrate. No activity with NADH, iron trichloride, Cu(2+) or Ag(+). May be involved in cytosolic ferric iron assimilation as an NADPH- dependent ferric reductase in vivo; Belongs to the ArsH family.
 
  
 0.916
arsB
Arsenical pump membrane protein; Identified by similarity to GB:AAF69238.1; match to protein family HMM PF02040; match to protein family HMM PF03600; match to protein family HMM TIGR00935.
  
  
 0.915
trx
Thioredoxin; Identified by match to protein family HMM PF00085; match to protein family HMM TIGR01068; Belongs to the thioredoxin family.
  
 
 0.725
AFE_1979
Thioredoxin; Identified by match to protein family HMM PF00085; match to protein family HMM TIGR01068; Belongs to the thioredoxin family.
  
 
 0.719
AFE_2362
Thioredoxin; Identified by match to protein family HMM PF00085; match to protein family HMM TIGR01068.
  
 
 0.719
AFE_3010
Polyketide synthase, type I, putative; Identified by similarity to GB:AAK26474.1; match to protein family HMM PF00106; match to protein family HMM PF00107; match to protein family HMM PF00109; match to protein family HMM PF00550; match to protein family HMM PF00698; match to protein family HMM PF02801; match to protein family HMM PF08240; match to protein family HMM PF08659.
  
 
 0.681
AFE_1340
Tyrosine-protein kinase, putative; Identified by similarity to SP:P38134; match to protein family HMM PF02706.
  
 
 0.588
AFE_1492
TonB-dependent receptor; Identified by match to protein family HMM PF00593; match to protein family HMM PF07715.
    
 
 0.581
AFE_2940
TonB-dependent receptor domain protein.
    
 
 0.581
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
Server load: low (14%) [HD]