Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AFE_2880Von Willebrand factor type A domain protein; Identified by match to protein family HMM PF00092. (225 aa)    
Predicted Functional Partners:
AFE_2879
Conserved hypothetical protein; Identified by similarity to SP:P76395.
 
    0.963
AFE_2877
Conserved hypothetical protein; Identified by similarity to SP:P76393.
     0.953
AFE_0707
Conserved hypothetical protein; Identified by similarity to PIR:AI1892.
  
     0.582
AFE_1053
Conserved domain protein; Identified by similarity to GB:AAF69908.1; match to protein family HMM PF01507.
  
     0.541
AFE_1221
Modification methylase, putative; Identified by similarity to SP:P11409.
  
     0.480
AFE_0711
NHL repeat protein; Identified by match to protein family HMM PF01436.
  
     0.454
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
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