Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ntrBNitrogen regulation protein NR(II); Identified by similarity to SP:P06218; match to protein family HMM PF00512; match to protein family HMM PF02518; match to protein family HMM PF08448. (361 aa)    
Predicted Functional Partners:
ntrC
Nitrogen regulation protein NR(I); Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes.
 0.998
glnB-2
Nitrogen regulatory protein P-II 1; Identified by similarity to SP:P05826; match to protein family HMM PF00543; Belongs to the P(II) protein family.
  
 0.959
glnB-1
Nitrogen regulatory protein P-II 1; Identified by similarity to SP:P05826; match to protein family HMM PF00543; Belongs to the P(II) protein family.
  
 0.959
glnA
Glutamine synthetase, type I; Identified by similarity to SP:P06711; match to protein family HMM PF00120; match to protein family HMM PF03951; match to protein family HMM TIGR00653.
 
  
 0.754
AFE_0447
Sigma-54 dependent DNA-binding response regulator; Identified by match to protein family HMM PF00072; match to protein family HMM PF00158; match to protein family HMM PF07728.
 
 0.632
AFE_2955
Sigma-54 dependent DNA-binding response regulator, putative; Identified by match to protein family HMM PF00072; match to protein family HMM PF00158.
 
 
 0.618
glnK-2
Nitrogen regulatory protein P-II 2; Identified by similarity to SP:P38504; match to protein family HMM PF00543.
  
 
 0.612
glnK-1
Nitrogen regulatory protein P-II 2; Identified by similarity to SP:P38504; match to protein family HMM PF00543; Belongs to the P(II) protein family.
  
 
 0.612
AFE_0027
Sigma-54 dependent transcriptional regulator/response regulator; Identified by similarity to SP:Q06065; match to protein family HMM PF00072; match to protein family HMM PF00158; match to protein family HMM PF02954.
 
 
 0.608
AFE_0185
Type IV fimbriae expression regulatory protein PilR, putative; Identified by similarity to SP:Q00934; match to protein family HMM PF00072; match to protein family HMM PF00158; match to protein family HMM PF02954.
 
 0.608
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
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