Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AFE_3020PTS system, IIA component, putative; Identified by match to protein family HMM PF03610. (138 aa)    
Predicted Functional Partners:
AFE_3023
Phosphoenolpyruvate-dependent sugar PTS system, EIIA component; Identified by match to protein family HMM PF00359.
 
 
 0.994
ptsH
Phosphocarrier protein HPr; Identified by similarity to SP:P23537; match to protein family HMM PF00381; match to protein family HMM TIGR01003.
 
 
 0.985
AFE_1366
Mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Identified by similarity to SP:P29956; match to protein family HMM PF00483; match to protein family HMM PF01050; match to protein family HMM PF07883; match to protein family HMM TIGR01479; Belongs to the mannose-6-phosphate isomerase type 2 family.
    
 0.914
AFE_2960
Mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Identified by match to protein family HMM PF00483; match to protein family HMM PF01050; match to protein family HMM PF07883; match to protein family HMM TIGR01479; Belongs to the mannose-6-phosphate isomerase type 2 family.
    
 0.914
AFE_3293
Mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Identified by similarity to SP:P29956; match to protein family HMM PF00483; match to protein family HMM PF01050; match to protein family HMM PF07883; match to protein family HMM TIGR01479; Belongs to the mannose-6-phosphate isomerase type 2 family.
    
 0.914
AFE_0943
Phosphomannomutase, putative; Identified by similarity to SP:P26405; match to protein family HMM PF00408; match to protein family HMM PF02878; match to protein family HMM PF02879; match to protein family HMM PF02880.
    
 0.901
hprK
Hpr(Ser) kinase/phosphatase; Identified by match to protein family HMM PF07475; Belongs to the HPrK/P family.
 
   
 0.877
AFE_1550
Carbohydrate kinase, PfkB family; Identified by match to protein family HMM PF00294.
    
 0.828
ptsI
Phosphoenolpyruvate-protein phosphotransferase; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).
 
  
 0.825
AFE_3021
ATPase; Displays ATPase and GTPase activities.
     
 0.809
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
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