Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
AFE_3023Phosphoenolpyruvate-dependent sugar PTS system, EIIA component; Identified by match to protein family HMM PF00359. (148 aa)    
Predicted Functional Partners:
AFE_3020
PTS system, IIA component, putative; Identified by match to protein family HMM PF03610.
 
 
 0.994
yfiA
Ribosomal subunit interface protein; Identified by similarity to SP:P24694; match to protein family HMM PF02482; match to protein family HMM TIGR00741.
 
  
 0.962
AFE_1807
Carbohydrate kinase, PfkB family; Identified by match to protein family HMM PF00294; match to protein family HMM TIGR03168; Belongs to the carbohydrate kinase PfkB family.
 
  
 0.954
AFE_3021
ATPase; Displays ATPase and GTPase activities.
  
  
 0.925
ptsI
Phosphoenolpyruvate-protein phosphotransferase; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).
 
  
 0.905
ptsH
Phosphocarrier protein HPr; Identified by similarity to SP:P23537; match to protein family HMM PF00381; match to protein family HMM TIGR01003.
 
  
 0.880
hprK
Hpr(Ser) kinase/phosphatase; Identified by match to protein family HMM PF07475; Belongs to the HPrK/P family.
 
   
 0.853
rpoN
RNA polymerase sigma-54 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
 
  
 0.775
lptA
Conserved hypothetical protein; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane.
  
  
 0.620
AFE_3026
ABC transporter, ATP-binding protein; Identified by match to protein family HMM PF00005.
  
  
 0.618
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
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