Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
rpoNRNA polymerase sigma-54 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (475 aa)    
Predicted Functional Partners:
AFE_0185
Type IV fimbriae expression regulatory protein PilR, putative; Identified by similarity to SP:Q00934; match to protein family HMM PF00072; match to protein family HMM PF00158; match to protein family HMM PF02954.
 
  
 0.953
AFE_0447
Sigma-54 dependent DNA-binding response regulator; Identified by match to protein family HMM PF00072; match to protein family HMM PF00158; match to protein family HMM PF07728.
 
  
 0.953
AFE_2955
Sigma-54 dependent DNA-binding response regulator, putative; Identified by match to protein family HMM PF00072; match to protein family HMM PF00158.
 
  
 0.952
AFE_0693
Sigma-54 dependent transcriptional regulator; Identified by match to protein family HMM PF00158; match to protein family HMM PF02954; match to protein family HMM PF07728.
  
  
 0.937
AFE_0184
Sensor protein PilS, putative; Identified by similarity to SP:P33639; match to protein family HMM PF00512; match to protein family HMM PF02518.
 
  
 0.928
AFE_0449
Sensor histidine kinase; Identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518.
     
 0.904
AFE_2957
Sensor histidine kinase; Identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518.
     
 0.904
rpoA
DNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
  
 
 0.898
rpoB
DNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 
 0.894
rpoZ
DNA-directed RNA polymerase, omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
   
 
 0.892
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
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