Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-expression
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[Homology]
Score
AFE_3062Conserved hypothetical protein; Identified by similarity to GB:BAC60875.1; match to protein family HMM PF02622; Belongs to the UPF0301 (AlgH) family. (185 aa)    
Predicted Functional Partners:
nrdA
Ribonucleotide-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
   
 0.975
AFE_3061
Conserved hypothetical protein; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA; Belongs to the YqgF HJR family.
  
  
 0.959
pyrB
Aspartate carbamoyltransferase; Identified by similarity to SP:Q59711; match to protein family HMM PF00185; match to protein family HMM PF02729; match to protein family HMM TIGR00670; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
  
    0.842
pyrC-1
Dihydroorotase, multifunctional complex type; Identified by similarity to SP:Q59712; match to protein family HMM PF01979; match to protein family HMM TIGR00857.
       0.805
pyrR
PyrR bifunctional protein; Identified by similarity to SP:P39765; match to protein family HMM PF00156.
       0.805
gshB
Glutathione synthetase; Identified by similarity to SP:P04425; match to protein family HMM PF02951; match to protein family HMM PF02955; match to protein family HMM PF08443; match to protein family HMM TIGR01380; Belongs to the prokaryotic GSH synthase family.
 
   
 0.748
dnaN
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
  
 
 0.740
gshA
Glutamate--cysteine ligase; Identified by match to protein family HMM PF08886; match to protein family HMM TIGR02049.
       0.626
AFE_0367
AhpC/TSA family/glutaredoxin domain protein; Identified by match to protein family HMM PF00462; match to protein family HMM PF00578; match to protein family HMM PF08534; match to protein family HMM TIGR02190.
  
 
 0.593
citZ
Citrate synthase II; Identified by similarity to SP:P39120; match to protein family HMM PF00285; match to protein family HMM TIGR01800; Belongs to the citrate synthase family.
       0.576
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
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