Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
pdhBPyruvate dehydrogenase, E1 component, pyruvate dehydrogenase beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (326 aa)    
Predicted Functional Partners:
AFE_1813
Dehydrogenase complex, E1 component, alpha subunit, putative; Identified by match to protein family HMM PF00676.
 0.999
pdhC
Pyruvate dehydrogenase complex, E2 and E3 components; Dihydrolipoamide acetyltransferase/dihydrolipoamide dehydrogenase; identified by similarity to PIR:C59237; match to protein family HMM PF00070; match to protein family HMM PF00198; match to protein family HMM PF00364; match to protein family HMM PF02817; match to protein family HMM PF02852; match to protein family HMM PF07992.
 
 0.999
pdhA
Pyruvate dehydrogenase complex, E1 component, pyruvate dehydrogenase alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
 0.999
AFE_1811
2-oxo acid dehydrogenase, acyltransferase, putative; Identified by match to protein family HMM PF00198; match to protein family HMM PF00364; match to protein family HMM PF02817.
 
 0.998
AFE_0958
Pyridine nucleotide-disulfide oxidoreductase; Identified by match to protein family HMM PF00070; match to protein family HMM PF02852; match to protein family HMM PF07992.
 
 0.978
AFE_1893
Pyridine nucleotide-disulfide oxidoreductase; Identified by match to protein family HMM PF00070; match to protein family HMM PF02852; match to protein family HMM PF07992.
 
 0.976
AFE_0660
Malic enzyme family protein; Identified by similarity to SP:O30808; match to protein family HMM PF00390; match to protein family HMM PF03949.
   
 
 0.944
prsA
Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
   
 0.918
AFE_0749
Pyruvate kinase barrel domain protein; Identified by match to protein family HMM PF00224.
  
 
 0.909
pyk
Pyruvate kinase; Identified by match to protein family HMM PF00224; match to protein family HMM PF02887; match to protein family HMM TIGR01064; Belongs to the pyruvate kinase family.
  
 
 0.909
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
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