Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AFE_3104DNA polymerase X family protein; Identified by match to protein family HMM PF00633; match to protein family HMM PF02811. (576 aa)    
Predicted Functional Partners:
polI
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
   
 0.895
AFE_2582
Histidinol-phosphate phosphatase domain protein; Identified by similarity to GB:AAO91485.1; match to protein family HMM TIGR01656; match to protein family HMM TIGR01662.
    
 0.859
AFE_3103
Phosphoribosyl transferase domain protein; Identified by similarity to GB:AAM31476.1; match to protein family HMM PF00156.
 
     0.832
dnaN
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
    
 0.774
hisIE
phosphoribosyl-AMP pyrophosphatase/phosphoribosyl-ATP cyclohydrolase; Identified by similarity to SP:O34912; match to protein family HMM PF01502; match to protein family HMM PF01503; match to protein family HMM TIGR03188; match to protein family HMM TIGR03456; In the N-terminal section; belongs to the PRA-CH family.
  
  
 0.699
xth-2
Exodeoxyribonuclease III; Identified by match to protein family HMM PF03372; match to protein family HMM TIGR00195; match to protein family HMM TIGR00633.
   
 0.679
xth-1
Exodeoxyribonuclease III; Identified by match to protein family HMM PF03372; match to protein family HMM TIGR00195; match to protein family HMM TIGR00633.
   
 0.679
AFE_2679
Identified by match to protein family HMM PF00753; match to protein family HMM PF07521.
    
 0.611
hisB
Imidazoleglycerol-phosphate dehydratase; Identified by match to protein family HMM PF00475.
  
  
 0.561
AFE_0463
formamidopyrimidine-DNA glycosylase, putative; Identified by match to protein family HMM PF06831; Belongs to the FPG family.
 
   
 0.505
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
Server load: low (10%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.