| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AFE_3127 | cobA | AFE_3127 | AFE_3126 | Conserved hypothetical protein; Identified by similarity to GB:CAD16125.1; match to protein family HMM PF01903. | uroporphyrin-III C-methyltransferase; Identified by similarity to SP:P21631; match to protein family HMM PF00590; match to protein family HMM TIGR01469; Belongs to the precorrin methyltransferase family. | 0.913 |
| AFE_3127 | cysC | AFE_3127 | AFE_0539 | Conserved hypothetical protein; Identified by similarity to GB:CAD16125.1; match to protein family HMM PF01903. | Sulfate adenylyltransferase, putative/adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. | 0.569 |
| AFE_3127 | cysH | AFE_3127 | AFE_3123 | Conserved hypothetical protein; Identified by similarity to GB:CAD16125.1; match to protein family HMM PF01903. | Adenylylsulfate reductase, thioredoxin dependent; Reduction of activated sulfate into sulfite. | 0.648 |
| AFE_3127 | cysI | AFE_3127 | AFE_3122 | Conserved hypothetical protein; Identified by similarity to GB:CAD16125.1; match to protein family HMM PF01903. | Sulfite reductase (NADPH) hemoprotein beta-component; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | 0.697 |
| AFE_3127 | cysJ | AFE_3127 | AFE_3121 | Conserved hypothetical protein; Identified by similarity to GB:CAD16125.1; match to protein family HMM PF01903. | Sulfite reductase (NADPH) flavoprotein, alpha component; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component. | 0.581 |
| cobA | AFE_3127 | AFE_3126 | AFE_3127 | uroporphyrin-III C-methyltransferase; Identified by similarity to SP:P21631; match to protein family HMM PF00590; match to protein family HMM TIGR01469; Belongs to the precorrin methyltransferase family. | Conserved hypothetical protein; Identified by similarity to GB:CAD16125.1; match to protein family HMM PF01903. | 0.913 |
| cobA | cysC | AFE_3126 | AFE_0539 | uroporphyrin-III C-methyltransferase; Identified by similarity to SP:P21631; match to protein family HMM PF00590; match to protein family HMM TIGR01469; Belongs to the precorrin methyltransferase family. | Sulfate adenylyltransferase, putative/adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. | 0.966 |
| cobA | cysH | AFE_3126 | AFE_3123 | uroporphyrin-III C-methyltransferase; Identified by similarity to SP:P21631; match to protein family HMM PF00590; match to protein family HMM TIGR01469; Belongs to the precorrin methyltransferase family. | Adenylylsulfate reductase, thioredoxin dependent; Reduction of activated sulfate into sulfite. | 0.884 |
| cobA | cysI | AFE_3126 | AFE_3122 | uroporphyrin-III C-methyltransferase; Identified by similarity to SP:P21631; match to protein family HMM PF00590; match to protein family HMM TIGR01469; Belongs to the precorrin methyltransferase family. | Sulfite reductase (NADPH) hemoprotein beta-component; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | 0.971 |
| cobA | cysJ | AFE_3126 | AFE_3121 | uroporphyrin-III C-methyltransferase; Identified by similarity to SP:P21631; match to protein family HMM PF00590; match to protein family HMM TIGR01469; Belongs to the precorrin methyltransferase family. | Sulfite reductase (NADPH) flavoprotein, alpha component; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component. | 0.805 |
| cobA | hemA | AFE_3126 | AFE_2761 | uroporphyrin-III C-methyltransferase; Identified by similarity to SP:P21631; match to protein family HMM PF00590; match to protein family HMM TIGR01469; Belongs to the precorrin methyltransferase family. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.811 |
| cobA | hemB | AFE_3126 | AFE_3298 | uroporphyrin-III C-methyltransferase; Identified by similarity to SP:P21631; match to protein family HMM PF00590; match to protein family HMM TIGR01469; Belongs to the precorrin methyltransferase family. | Delta-aminolevulinic acid dehydratase; Identified by match to protein family HMM PF00490; Belongs to the ALAD family. | 0.896 |
| cobA | hemC | AFE_3126 | AFE_3300 | uroporphyrin-III C-methyltransferase; Identified by similarity to SP:P21631; match to protein family HMM PF00590; match to protein family HMM TIGR01469; Belongs to the precorrin methyltransferase family. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.991 |
| cobA | hemD | AFE_3126 | AFE_3299 | uroporphyrin-III C-methyltransferase; Identified by similarity to SP:P21631; match to protein family HMM PF00590; match to protein family HMM TIGR01469; Belongs to the precorrin methyltransferase family. | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.974 |
| cobA | hemE | AFE_3126 | AFE_0728 | uroporphyrin-III C-methyltransferase; Identified by similarity to SP:P21631; match to protein family HMM PF00590; match to protein family HMM TIGR01469; Belongs to the precorrin methyltransferase family. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.939 |
| cysC | AFE_3127 | AFE_0539 | AFE_3127 | Sulfate adenylyltransferase, putative/adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. | Conserved hypothetical protein; Identified by similarity to GB:CAD16125.1; match to protein family HMM PF01903. | 0.569 |
| cysC | cobA | AFE_0539 | AFE_3126 | Sulfate adenylyltransferase, putative/adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. | uroporphyrin-III C-methyltransferase; Identified by similarity to SP:P21631; match to protein family HMM PF00590; match to protein family HMM TIGR01469; Belongs to the precorrin methyltransferase family. | 0.966 |
| cysC | cysH | AFE_0539 | AFE_3123 | Sulfate adenylyltransferase, putative/adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. | Adenylylsulfate reductase, thioredoxin dependent; Reduction of activated sulfate into sulfite. | 0.993 |
| cysC | cysI | AFE_0539 | AFE_3122 | Sulfate adenylyltransferase, putative/adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. | Sulfite reductase (NADPH) hemoprotein beta-component; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | 0.990 |
| cysC | cysJ | AFE_0539 | AFE_3121 | Sulfate adenylyltransferase, putative/adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. | Sulfite reductase (NADPH) flavoprotein, alpha component; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component. | 0.975 |
