Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
AFE_3137DNA-binding response regulator; Identified by match to protein family HMM PF00072; match to protein family HMM PF02954. (171 aa)    
Predicted Functional Partners:
AFE_3136
Sensor histidine kinase; Identified by match to protein family HMM PF00512; match to protein family HMM PF02518.
 
 0.994
AFE_0957
Sigma-54 dependent transcriptional regulator; Identified by match to protein family HMM PF00158; match to protein family HMM PF07728.
  
   
 0.775
AFE_0026
Sensor histidine kinase; Identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518.
 
 
 
 0.652
phoB
DNA-binding response regulator PhoB; Identified by similarity to SP:P45605; match to protein family HMM PF00072; match to protein family HMM PF00486; match to protein family HMM TIGR02154.
  
 
 
 0.547
cbbR
Rubisco operon transcriptional regulator; Identified by similarity to SP:Q06610; match to protein family HMM PF00126; match to protein family HMM PF03466; Belongs to the LysR transcriptional regulatory family.
    
 
 0.505
AFE_2319
DNA-binding response regulator; Identified by match to protein family HMM PF00072; match to protein family HMM PF00486.
  
 
 
 0.486
AFE_2032
DNA-binding response regulator; Identified by match to protein family HMM PF00072; match to protein family HMM PF00486.
  
 
 
 0.479
kdpE
DNA-binding response regulator KdpE; Identified by match to protein family HMM PF00072; match to protein family HMM PF00486.
  
 
 
 0.454
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
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