Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
coxCCytochrome c oxidase, aa3-type, subunit III; Identified by similarity to GB:CAA07036.1. (184 aa)    
Predicted Functional Partners:
coxB
Cytochrome c oxidase, aa3-type, subunit II; Identified by similarity to GB:CAA07034.1; match to protein family HMM PF00116.
    
 0.986
coxA
Cytochrome c oxidase, aa3-type, subunit I; Identified by similarity to GB:CAA07035.1; match to protein family HMM PF00115.
    
  0.971
cyoE-1
Protoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
     
 0.941
cyoB
Cytochrome o ubiquinol oxidase, subunit I; Identified by similarity to SP:P18401; match to protein family HMM PF00115; Belongs to the heme-copper respiratory oxidase family.
     
 0.928
cyoC
Cytochrome o ubiquinol oxidase, subunit III; Identified by similarity to SP:P18402.
     
 0.926
cyoA
Cytochrome o ubiquinol oxidase, subunit II; Identified by similarity to SP:P18400; match to protein family HMM PF00116; match to protein family HMM PF06481.
     
 0.917
cyoD
Cytochrome o ubiquinol oxidase, subunit IV; Identified by similarity to SP:P18403.
     
  0.900
coxD
Cytochrome c oxidase, aa3-type, subunit IV; Identified by similarity to GB:BAC22706.1.
     
 0.900
cyc1
Cytochrome c552; Identified by similarity to SP:P74917; match to protein family HMM PF00034.
     
 0.656
cyc2
Cytochrome c; Identified by similarity to GB:CAA07031.1.
     
 0.652
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
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