Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
coxACytochrome c oxidase, aa3-type, subunit I; Identified by similarity to GB:CAA07035.1; match to protein family HMM PF00115. (627 aa)    
Predicted Functional Partners:
cyoC
Cytochrome o ubiquinol oxidase, subunit III; Identified by similarity to SP:P18402.
 
 0.999
coxB
Cytochrome c oxidase, aa3-type, subunit II; Identified by similarity to GB:CAA07034.1; match to protein family HMM PF00116.
 
 0.999
cyoA
Cytochrome o ubiquinol oxidase, subunit II; Identified by similarity to SP:P18400; match to protein family HMM PF00116; match to protein family HMM PF06481.
 
 0.998
cyoD
Cytochrome o ubiquinol oxidase, subunit IV; Identified by similarity to SP:P18403.
  
 0.994
cyoE-1
Protoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
 
 0.994
petB-1
Ubiquinol--cytochrome c reductase, cytochrome b subunit; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.
 
 
 0.971
coxC
Cytochrome c oxidase, aa3-type, subunit III; Identified by similarity to GB:CAA07036.1.
    
  0.971
nuoH
NADH-quinone oxidoreductase, H subunit; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.
  
 
 0.967
petB-2
Ubiquinol--cytochrome c reductase, cytochrome b subunit; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.
 
 
 0.966
nuoM
NADH-quinone oxidoreductase, M subunit; Identified by similarity to SP:P50974; match to protein family HMM PF00361; match to protein family HMM TIGR01972.
  
 
 0.965
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
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