Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AFE_3193PHP domain protein. (894 aa)    
Predicted Functional Partners:
AFE_3194
ATP-dependent DNA helicase RecG domain protein; Identified by similarity to SP:O50224; match to protein family HMM PF04326.
 
     0.835
AFE_3191
Type III restriction-modification system, Res subunit; Identified by match to protein family HMM PF04851.
  
    0.621
AFE_3192
Type III restriction-modification system, Mod subunit; Identified by match to protein family HMM PF01555.
       0.608
recA
recA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
  
 0.503
cyc2
Cytochrome c; Identified by similarity to GB:CAA07031.1.
  
     0.493
AFE_1869
Cell division inhibitor, putative; Identified by similarity to SP:P08845.
   
    0.490
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
  
  
 0.470
AFE_1428
Cytochrome c; Identified by similarity to GB:CAA07031.1.
  
     0.461
AFE_0763
TonB-dependent receptor, putative; Identified by match to protein family HMM PF00593; match to protein family HMM PF07715.
  
     0.453
AFE_3229
TonB-dependent receptor; Identified by match to protein family HMM PF00593; match to protein family HMM PF07715.
  
     0.440
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
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