Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
trpCIndole-3-glycerol phosphate synthase; Identified by similarity to SP:P20577; match to protein family HMM PF00218; Belongs to the TrpC family. (263 aa)    
Predicted Functional Partners:
trpB
Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
 
 0.999
trpF
N-(5'phosphoribosyl)anthranilate isomerase; Identified by similarity to SP:Q56320; match to protein family HMM PF00697; Belongs to the TrpF family.
 
 0.999
trpD
Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA).
  
 0.999
pabA
Para-aminobenzoate synthase glutamine amidotransferase component II; Identified by similarity to PIR:A01122; match to protein family HMM PF00117; match to protein family HMM TIGR00566.
  
 0.999
trpE
Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...]
 
 0.999
trpA
Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
 
 
 0.998
pabB
Para-aminobenzoate synthase, component I; Identified by similarity to SP:P05041; match to protein family HMM PF00425; match to protein family HMM PF04715; match to protein family HMM TIGR00553.
 
 0.986
hisA
Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by similarity to SP:O35006; match to protein family HMM PF00977; match to protein family HMM TIGR00007.
  
  
 0.823
pheA
Chorismate mutase/prephenate dehydratase; Identified by similarity to SP:P27603; match to protein family HMM PF00800; match to protein family HMM PF01817; match to protein family HMM PF01842; match to protein family HMM TIGR01807.
 
  
 0.775
tyrA
Prephenate dehydrogenase; Identified by similarity to SP:P20692; match to protein family HMM PF02153.
 
   
 0.737
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
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