Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
gmd-2GDP-mannose 4,6-dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose. (343 aa)    
Predicted Functional Partners:
AFE_3293
Mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Identified by similarity to SP:P29956; match to protein family HMM PF00483; match to protein family HMM PF01050; match to protein family HMM PF07883; match to protein family HMM TIGR01479; Belongs to the mannose-6-phosphate isomerase type 2 family.
  
 
 0.988
AFE_3291
Identified by match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF02719; match to protein family HMM PF04321; match to protein family HMM PF07993.
 
0.985
AFE_1366
Mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Identified by similarity to SP:P29956; match to protein family HMM PF00483; match to protein family HMM PF01050; match to protein family HMM PF07883; match to protein family HMM TIGR01479; Belongs to the mannose-6-phosphate isomerase type 2 family.
  
 
 0.949
AFE_2960
Mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Identified by match to protein family HMM PF00483; match to protein family HMM PF01050; match to protein family HMM PF07883; match to protein family HMM TIGR01479; Belongs to the mannose-6-phosphate isomerase type 2 family.
  
 
 0.949
gmd-1
GDP-mannose 4,6-dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose.
  
  
 
0.900
prsA
Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
   
 
 0.744
rpiA
Ribose 5-phosphate isomerase A; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
      
 0.724
AFE_0073
Undecaprenyl-phosphate galactosephosphotransferase; Identified by similarity to SP:P26406; match to protein family HMM PF02397; match to protein family HMM TIGR03022; match to protein family HMM TIGR03025.
  
  
 0.572
AFE_1370
Undecaprenyl-phosphate galactosephosphotransferase, putative; Identified by similarity to SP:P26406; match to protein family HMM PF02397; match to protein family HMM TIGR03022; match to protein family HMM TIGR03025.
  
  
 0.572
AFE_1340
Tyrosine-protein kinase, putative; Identified by similarity to SP:P38134; match to protein family HMM PF02706.
  
  
 0.470
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
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