Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AFE_3301Competence protein ComEA helix-hairpin-helix repeat protein; Identified by match to protein family HMM PF00633. (91 aa)    
Predicted Functional Partners:
hemD
uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
       0.631
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
       0.631
pilD
Type IV pilus prepilin peptidase PilD; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue.
   
  
 0.574
AFE_3302
HIT family protein; Identified by match to protein family HMM PF01230.
       0.552
hemL
Glutamate-1-semialdehyde-2,1-aminomutase; Identified by similarity to SP:P48247; match to protein family HMM PF00202; match to protein family HMM TIGR00713.
       0.537
thiE
Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
       0.537
AFE_3305
Phosphomethylpyrimidine kinase, putative; Identified by match to protein family HMM PF08543.
       0.537
pilC
Type IV pilus biogenesis protein PilC; Identified by similarity to SP:P45793; match to protein family HMM PF00482.
  
  
 0.490
AFE_3297
Identified by match to protein family HMM TIGR01352.
       0.480
hemB
Delta-aminolevulinic acid dehydratase; Identified by match to protein family HMM PF00490; Belongs to the ALAD family.
       0.480
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
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