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hisH protein (Burkholderia mallei) - STRING interaction network
"hisH" - Imidazole glycerol phosphate synthase subunit HisH in Burkholderia mallei
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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hisHImidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (213 aa)    
Predicted Functional Partners:
hisF
Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (257 aa)
  0.999
hisB
Imidazoleglycerol-phosphate dehydratase; Identified by similarity to SP-Q05068; match to protein family HMM PF00475 (195 aa)
 
 
  0.999
hisA
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Identified by similarity to SP-P05325; match to protein family HMM PF00977 (251 aa)
 
  0.999
hisD
Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (445 aa)
   
  0.996
hisI
Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP (137 aa)
 
   
  0.979
hisG
ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N’-(5’-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity; Belongs to the ATP phosphoribosyltransferase family. Short subfamily (218 aa)
 
   
  0.967
hisE
Phosphoribosyl-ATP pyrophosphatase; Identified by similarity to SP-O30723; match to protein family HMM PF01503 (122 aa)
 
   
  0.942
hisC-1
Histidinol-phosphate aminotransferase 1; Identified by similarity to SP-P16246; match to protein family HMM PF00155; match to protein family HMM TIGR01141; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily (356 aa)
 
   
  0.937
hisC-2
Histidinol-phosphate aminotransferase 2; Identified by similarity to SP-P45358; match to protein family HMM PF00155; match to protein family HMM TIGR01141; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily (356 aa)
 
   
  0.873
BMA2711
UPF0056 inner membrane protein; Identified by similarity to GP-17429972; match to protein family HMM PF01914; match to protein family HMM TIGR00427 (206 aa)
         
  0.867
Your Current Organism:
Burkholderia mallei
NCBI taxonomy Id: 243160
Other names: B. mallei ATCC 23344, Burkholderia mallei, Burkholderia mallei ATCC 23344, Burkholderia mallei ATCC23344, Burkholderia mallei str. ATCC 23344
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