STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DET0066DNA methylase; Identified by match to protein family HMM PF01555; match to protein family HMM PF02195; Belongs to the N(4)/N(6)-methyltransferase family. (411 aa)    
Predicted Functional Partners:
DET0065
Virulence-related protein; Identified by similarity to GP:3482866.
 
     0.847
metK-1
S-adenosylmethionine synthetase; Identified by similarity to SP:P54419; match to protein family HMM PF00438; match to protein family HMM PF02772; match to protein family HMM TIGR01034; Belongs to the AdoMet synthase family.
       0.828
gidB
Methyltransferase GidB; Specifically methylates the N7 position of a guanine in 16S rRNA; Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
  
  
 0.776
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
  
  
 0.701
DET1091
Virulence-related protein; Identified by similarity to GP:3482866.
 
     0.690
guaA
GMP synthase; Catalyzes the synthesis of GMP from XMP.
     
 0.674
DET1093
Hypothetical protein; Identified by Glimmer2; putative.
 
    0.607
ssb
Single-strand binding protein; Identified by match to protein family HMM TIGR00621.
     
 0.568
polA
DNA-directed DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
  
 0.553
DET1294
DNA-binding response regulator; Identified by match to protein family HMM TIGR01764.
     
 0.552
Your Current Organism:
Dehalococcoides mccartyi
NCBI taxonomy Id: 243164
Other names: D. mccartyi 195, Dehalococcoides ethenogenes 195, Dehalococcoides mccartyi 195, Dehalococcoides mccartyi str. 195, Dehalococcoides mccartyi strain 195
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