STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DET0074DNA-dependent DNA polymerase, family A; Identified by similarity to SP:P06225. (646 aa)    
Predicted Functional Partners:
sbcD
Nuclease SbcCD, D subunit; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family.
   
 0.828
polA
DNA-directed DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 
0.823
DET0071
SNF2 family helicase, putative.
 
 
   0.822
DET1096
SNF2 domain protein.
  
 
   0.783
DET0549
Exonuclease SbcC, putative; Identified by similarity to SP:P13458.
   
 
 0.782
DET1097
Conserved hypothetical protein; Identified by similarity to OMNI:EF0329.
 
     0.782
DET1101
Conserved hypothetical protein; Identified by similarity to GP:18920552.
 
     0.782
DET1102
Conserved hypothetical protein; Identified by similarity to OMNI:EF0319.
 
     0.782
DET1107
Conserved domain protein; Identified by similarity to GP:29341852.
   
 
 0.782
DET1098
Virulence-associated protein E, putative; Identified by similarity to GP:563258; match to protein family HMM PF05272.
 
     0.773
Your Current Organism:
Dehalococcoides mccartyi
NCBI taxonomy Id: 243164
Other names: D. mccartyi 195, Dehalococcoides ethenogenes 195, Dehalococcoides mccartyi 195, Dehalococcoides mccartyi str. 195, Dehalococcoides mccartyi strain 195
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.