| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DET0395 | DET0396 | DET0395 | DET0396 | Glycoprotease family protein/hydrolase, beta-phosphoglucomutase family; Identified by match to protein family HMM PF00814; match to protein family HMM TIGR01509; match to protein family HMM TIGR01549; match to protein family HMM TIGR02009. | Identified by similarity to GP:29894046; match to protein family HMM TIGR00150. | 0.999 |
| DET0395 | adk | DET0395 | DET0495 | Glycoprotease family protein/hydrolase, beta-phosphoglucomutase family; Identified by match to protein family HMM PF00814; match to protein family HMM TIGR01509; match to protein family HMM TIGR01549; match to protein family HMM TIGR02009. | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | 0.404 |
| DET0395 | ndk | DET0395 | DET0394 | Glycoprotease family protein/hydrolase, beta-phosphoglucomutase family; Identified by match to protein family HMM PF00814; match to protein family HMM TIGR01509; match to protein family HMM TIGR01549; match to protein family HMM TIGR02009. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.874 |
| DET0395 | ribD | DET0395 | DET1190 | Glycoprotease family protein/hydrolase, beta-phosphoglucomutase family; Identified by match to protein family HMM PF00814; match to protein family HMM TIGR01509; match to protein family HMM TIGR01549; match to protein family HMM TIGR02009. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.565 |
| DET0395 | thiE | DET0395 | DET0782 | Glycoprotease family protein/hydrolase, beta-phosphoglucomutase family; Identified by match to protein family HMM PF00814; match to protein family HMM TIGR01509; match to protein family HMM TIGR01549; match to protein family HMM TIGR02009. | ThiE-associated domain protein/thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. | 0.523 |
| DET0395 | thiL | DET0395 | DET0397 | Glycoprotease family protein/hydrolase, beta-phosphoglucomutase family; Identified by match to protein family HMM PF00814; match to protein family HMM TIGR01509; match to protein family HMM TIGR01549; match to protein family HMM TIGR02009. | Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. | 0.904 |
| DET0396 | DET0395 | DET0396 | DET0395 | Identified by similarity to GP:29894046; match to protein family HMM TIGR00150. | Glycoprotease family protein/hydrolase, beta-phosphoglucomutase family; Identified by match to protein family HMM PF00814; match to protein family HMM TIGR01509; match to protein family HMM TIGR01549; match to protein family HMM TIGR02009. | 0.999 |
| DET0396 | ndk | DET0396 | DET0394 | Identified by similarity to GP:29894046; match to protein family HMM TIGR00150. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.791 |
| DET0396 | thiL | DET0396 | DET0397 | Identified by similarity to GP:29894046; match to protein family HMM TIGR00150. | Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. | 0.950 |
| adk | DET0395 | DET0495 | DET0395 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | Glycoprotease family protein/hydrolase, beta-phosphoglucomutase family; Identified by match to protein family HMM PF00814; match to protein family HMM TIGR01509; match to protein family HMM TIGR01549; match to protein family HMM TIGR02009. | 0.404 |
| adk | ndk | DET0495 | DET0394 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.942 |
| adk | thiL | DET0495 | DET0397 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. | 0.900 |
| ndk | DET0395 | DET0394 | DET0395 | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | Glycoprotease family protein/hydrolase, beta-phosphoglucomutase family; Identified by match to protein family HMM PF00814; match to protein family HMM TIGR01509; match to protein family HMM TIGR01549; match to protein family HMM TIGR02009. | 0.874 |
| ndk | DET0396 | DET0394 | DET0396 | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | Identified by similarity to GP:29894046; match to protein family HMM TIGR00150. | 0.791 |
| ndk | adk | DET0394 | DET0495 | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | 0.942 |
| ndk | ribBA | DET0394 | DET1188 | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. | 0.867 |
| ndk | thiL | DET0394 | DET0397 | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. | 0.814 |
| nrdR | ribBA | DET0344 | DET1188 | Conserved hypothetical protein TIGR00244; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. | 0.696 |
| nrdR | ribD | DET0344 | DET1190 | Conserved hypothetical protein TIGR00244; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.832 |
| nrdR | ribH | DET0344 | DET1187 | Conserved hypothetical protein TIGR00244; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. | 0.448 |
