STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mdhMalate dehydrogenase, NAD-dependent; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (307 aa)    
Predicted Functional Partners:
DET0453
Fumarate hydratase, alpha subunit, putative; Identified by similarity to SP:Q58690; match to protein family HMM PF05681; match to protein family HMM TIGR00722.
  
 
 0.988
DET0454
Fumarate hydratase, beta subunit, putative; Identified by similarity to SP:P14407; match to protein family HMM PF05683; match to protein family HMM TIGR00723.
  
 
 0.988
oadA
Oxaloacetate decarboxylase, alpha subunit; Identified by similarity to SP:Q03030; match to protein family HMM PF02436; match to protein family HMM TIGR01108.
    
 0.963
DET1164
Iron-sulfur cluster-binding protein.
  
  
 0.919
DET1614
Homocitrate synthase; Identified by similarity to SP:Q44290.
   
 0.912
accC
acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.
     
 0.911
gap
Glyceraldehyde-3-phosphate dehydrogenase, type I; Identified by match to protein family HMM PF00044; match to protein family HMM TIGR01534; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
  
 
 0.851
purB
Adenylosuccinate lyase; Identified by similarity to SP:P12047; match to protein family HMM PF00206; match to protein family HMM TIGR00928; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
   
 0.838
argH
Argininosuccinate lyase; Identified by similarity to SP:O34858; match to protein family HMM TIGR00838.
   
 0.836
DET0187
Formate dehydrogenase, alpha subunit; Identified by match to protein family HMM TIGR01409; match to protein family HMM TIGR01553; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.
     
 0.815
Your Current Organism:
Dehalococcoides mccartyi
NCBI taxonomy Id: 243164
Other names: D. mccartyi 195, Dehalococcoides ethenogenes 195, Dehalococcoides mccartyi 195, Dehalococcoides mccartyi str. 195, Dehalococcoides mccartyi strain 195
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