STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-occurrence
Co-expression
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[Homology]
Score
mdhMalate dehydrogenase, NAD-dependent; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (307 aa)    
Predicted Functional Partners:
DET0454
Fumarate hydratase, beta subunit, putative; Identified by similarity to SP:P14407; match to protein family HMM PF05683; match to protein family HMM TIGR00723.
  
 
 0.989
DET0453
Fumarate hydratase, alpha subunit, putative; Identified by similarity to SP:Q58690; match to protein family HMM PF05681; match to protein family HMM TIGR00722.
  
 
 0.988
oadA
Oxaloacetate decarboxylase, alpha subunit; Identified by similarity to SP:Q03030; match to protein family HMM PF02436; match to protein family HMM TIGR01108.
    
 0.964
groEL
Co-chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
   
 0.947
atpA
ATP synthase F1, alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family.
  
 0.932
accC
acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.
     
 0.911
DET1614
Homocitrate synthase; Identified by similarity to SP:Q44290.
   
 0.908
DET1164
Iron-sulfur cluster-binding protein.
  
  
 0.898
DET0450
Isocitrate dehydrogenase, putative; Identified by similarity to SP:P33197; match to protein family HMM PF00180.
  
 0.872
purB
Adenylosuccinate lyase; Identified by similarity to SP:P12047; match to protein family HMM PF00206; match to protein family HMM TIGR00928; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
   
 0.849
Your Current Organism:
Dehalococcoides mccartyi
NCBI taxonomy Id: 243164
Other names: D. mccartyi 195, Dehalococcoides ethenogenes 195, Dehalococcoides mccartyi 195, Dehalococcoides mccartyi str. 195, Dehalococcoides mccartyi strain 195
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