Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
serAD-3-phosphoglycerate dehydrogenase; Identified by similarity to SP:P35136; match to protein family HMM TIGR01327; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (526 aa)    
Predicted Functional Partners:
DET0743
Phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent, putative; Identified by similarity to SP:O66820; match to protein family HMM TIGR00306.
     
  0.900
DET1635
Bisphosphoglycerate-independent phosphoglycerate mutase family protein; Identified by similarity to SP:P58812; match to protein family HMM PF01676; match to protein family HMM TIGR00306.
     
  0.900
DET0600
Soluble hydrogenase, tritium exchange subunit; Identified by similarity to SP:P16421.
 
  
 0.870
tyrS
tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily.
  
   0.614
DET0330
Identified by match to protein family HMM PF00850.
    
 0.612
ribF
Riboflavin biosynthesis protein RibF; Identified by similarity to SP:Q59263; match to protein family HMM PF01687; match to protein family HMM TIGR00083; Belongs to the ribF family.
       0.609
pdxT
SNO glutamine amidotransferase family; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
  
    0.602
nadE
Glutamine-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
     
 0.536
thrC
Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine.
   
  
 0.509
rplF
Ribosomal protein L6; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family.
    
   0.501
Your Current Organism:
Dehalococcoides mccartyi
NCBI taxonomy Id: 243164
Other names: D. mccartyi 195, Dehalococcoides ethenogenes 195, Dehalococcoides mccartyi 195, Dehalococcoides mccartyi str. 195, Dehalococcoides mccartyi strain 195
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