DET0677 protein (Dehalococcoides mccartyi) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

DET0677

Ribose-5-phosphate isomerase, putative; Identified by match to protein family HMM TIGR00689; match to protein family HMM TIGR01120. (152 aa)

Predicted Functional Partners:

glyA

0.927

tkt-2

0.795

DET0679

0.634

guaA

0.550

DET0680

0.456

ribBA

0.414

Your Current Organism:

Dehalococcoides mccartyi

NCBI taxonomy Id: 243164
Other names: D. mccartyi 195, Dehalococcoides ethenogenes 195, Dehalococcoides mccartyi 195, Dehalococcoides mccartyi str. 195, Dehalococcoides mccartyi strain 195

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DET0677	DET0679	DET0677	DET0679	Ribose-5-phosphate isomerase, putative; Identified by match to protein family HMM TIGR00689; match to protein family HMM TIGR01120.	Nitroreductase family protein; Identified by similarity to OMNI:NTL01CA1531.	0.634
DET0677	DET0680	DET0677	DET0680	Ribose-5-phosphate isomerase, putative; Identified by match to protein family HMM TIGR00689; match to protein family HMM TIGR01120.	Conserved hypothetical protein; Identified by similarity to OMNI:NTL02MA4536.	0.456
DET0677	glyA	DET0677	DET0436	Ribose-5-phosphate isomerase, putative; Identified by match to protein family HMM TIGR00689; match to protein family HMM TIGR01120.	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.927
DET0677	guaA	DET0677	DET0836	Ribose-5-phosphate isomerase, putative; Identified by match to protein family HMM TIGR00689; match to protein family HMM TIGR01120.	GMP synthase; Catalyzes the synthesis of GMP from XMP.	0.550
DET0677	ribBA	DET0677	DET1188	Ribose-5-phosphate isomerase, putative; Identified by match to protein family HMM TIGR00689; match to protein family HMM TIGR01120.	3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family.	0.414
DET0677	tkt-2	DET0677	DET0678	Ribose-5-phosphate isomerase, putative; Identified by match to protein family HMM TIGR00689; match to protein family HMM TIGR01120.	Transketolase; Identified by match to protein family HMM TIGR00232.	0.795
DET0679	DET0677	DET0679	DET0677	Nitroreductase family protein; Identified by similarity to OMNI:NTL01CA1531.	Ribose-5-phosphate isomerase, putative; Identified by match to protein family HMM TIGR00689; match to protein family HMM TIGR01120.	0.634
DET0679	DET0680	DET0679	DET0680	Nitroreductase family protein; Identified by similarity to OMNI:NTL01CA1531.	Conserved hypothetical protein; Identified by similarity to OMNI:NTL02MA4536.	0.534
DET0679	tkt-2	DET0679	DET0678	Nitroreductase family protein; Identified by similarity to OMNI:NTL01CA1531.	Transketolase; Identified by match to protein family HMM TIGR00232.	0.641
DET0680	DET0677	DET0680	DET0677	Conserved hypothetical protein; Identified by similarity to OMNI:NTL02MA4536.	Ribose-5-phosphate isomerase, putative; Identified by match to protein family HMM TIGR00689; match to protein family HMM TIGR01120.	0.456
DET0680	DET0679	DET0680	DET0679	Conserved hypothetical protein; Identified by similarity to OMNI:NTL02MA4536.	Nitroreductase family protein; Identified by similarity to OMNI:NTL01CA1531.	0.534
DET0680	tkt-2	DET0680	DET0678	Conserved hypothetical protein; Identified by similarity to OMNI:NTL02MA4536.	Transketolase; Identified by match to protein family HMM TIGR00232.	0.447
glyA	DET0677	DET0436	DET0677	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Ribose-5-phosphate isomerase, putative; Identified by match to protein family HMM TIGR00689; match to protein family HMM TIGR01120.	0.927
glyA	guaA	DET0436	DET0836	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	GMP synthase; Catalyzes the synthesis of GMP from XMP.	0.689
glyA	ribBA	DET0436	DET1188	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family.	0.728
guaA	DET0677	DET0836	DET0677	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Ribose-5-phosphate isomerase, putative; Identified by match to protein family HMM TIGR00689; match to protein family HMM TIGR01120.	0.550
guaA	glyA	DET0836	DET0436	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.689
guaA	ribBA	DET0836	DET1188	GMP synthase; Catalyzes the synthesis of GMP from XMP.	3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family.	0.697
guaA	tkt-2	DET0836	DET0678	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Transketolase; Identified by match to protein family HMM TIGR00232.	0.485
ribBA	DET0677	DET1188	DET0677	3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family.	Ribose-5-phosphate isomerase, putative; Identified by match to protein family HMM TIGR00689; match to protein family HMM TIGR01120.	0.414

page 1 of 2

Server load: low (24%) [HD]

Permalink

Network

Neighborhood

Experiments

Fusion

Textmining

Co-occurrence

Databases

Co-expression

© STRING Consortium 2026

Credits

Access

Info

About