STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DET1065RNA methyltransferase, TrmA family; Identified by match to protein family HMM PF05958; match to protein family HMM TIGR00479; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (395 aa)    
Predicted Functional Partners:
maF
Septum formation protein MaF; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
     0.929
DET1063
DNA-binding response regulator, LuxR family.
       0.531
DET1064
Sensory box sensor histidine kinase; Identified by similarity to OMNI:NTL02MA1586; match to protein family HMM TIGR00229.
       0.531
DET0224
ABC transporter, ATP-binding protein; Identified by similarity to SP:P45535.
  
    0.477
guaA
GMP synthase; Catalyzes the synthesis of GMP from XMP.
   
  
 0.470
relA
GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.
     0.460
tgt
Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form th [...]
 
  
 0.460
DET0395
Glycoprotease family protein/hydrolase, beta-phosphoglucomutase family; Identified by match to protein family HMM PF00814; match to protein family HMM TIGR01509; match to protein family HMM TIGR01549; match to protein family HMM TIGR02009.
 
  
 0.457
rsmI
Tetrapyrrole methylase family protein; Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
  
  
 0.451
DET1066
Hypothetical protein; Identified by Glimmer2; putative.
       0.449
Your Current Organism:
Dehalococcoides mccartyi
NCBI taxonomy Id: 243164
Other names: D. mccartyi 195, Dehalococcoides ethenogenes 195, Dehalococcoides mccartyi 195, Dehalococcoides mccartyi str. 195, Dehalococcoides mccartyi strain 195
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