STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
DET1127Conserved hypothetical protein; Identified by similarity to OMNI:TM0394. (256 aa)    
Predicted Functional Partners:
DET1130
Glutamine amidotransferase, class II; Identified by similarity to SP:O29310; match to protein family HMM PF00310.
 
   0.998
gltB
Glutamate synthase, alpha subunit, putative; Belongs to the glutamate synthase family.
 
   0.965
DET0123
Pyridine nucleotide-disulphide oxidoreductase family protein.
  
 
 0.952
DET0866
Hydrogenase subunit, putative; Identified by similarity to SP:P76440.
  
 
 0.948
gltA
Glutamate synthase (NADPH), homotetrameric; Identified by match to protein family HMM TIGR01316.
  
 
 0.939
DET1131
Pyridine nucleotide-disulfide oxidoreductase family protein.
 
   
 0.868
hisF
Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
  
    0.789
DET1133
Iron-sulfur cluster-binding protein.
 
     0.789
hisH
Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
       0.777
DET1126
Transcriptional regulator; Identified by similarity to SP:Q05943.
       0.714
Your Current Organism:
Dehalococcoides mccartyi
NCBI taxonomy Id: 243164
Other names: D. mccartyi 195, Dehalococcoides ethenogenes 195, Dehalococcoides mccartyi 195, Dehalococcoides mccartyi str. 195, Dehalococcoides mccartyi strain 195
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