| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DET0024 | radA | DET0024 | DET0058 | DNA internalization-related competence protein ComEC/Rec2; Identified by match to protein family HMM TIGR00360; match to protein family HMM TIGR00361. | DNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. | 0.522 |
| DET0024 | ribBA | DET0024 | DET1188 | DNA internalization-related competence protein ComEC/Rec2; Identified by match to protein family HMM TIGR00360; match to protein family HMM TIGR00361. | 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. | 0.709 |
| DET0024 | uvrA | DET0024 | DET0546 | DNA internalization-related competence protein ComEC/Rec2; Identified by match to protein family HMM TIGR00360; match to protein family HMM TIGR00361. | Excinuclease ABC, A subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. | 0.400 |
| DET0024 | uvrB | DET0024 | DET0441 | DNA internalization-related competence protein ComEC/Rec2; Identified by match to protein family HMM TIGR00360; match to protein family HMM TIGR00361. | Excinuclease ABC, B subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] | 0.538 |
| DET0024 | uvrC | DET0024 | DET1216 | DNA internalization-related competence protein ComEC/Rec2; Identified by match to protein family HMM TIGR00360; match to protein family HMM TIGR00361. | Excinuclease ABC, C subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. | 0.640 |
| guaA | mutL | DET0836 | DET1195 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | DNA mismatch repair protein, MutL/HexB family; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | 0.422 |
| guaA | mutM | DET0836 | DET1389 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | formamidopyrimidine-DNA glycosylase; Identified by match to protein family HMM PF01149; match to protein family HMM TIGR00577. | 0.419 |
| guaA | pcrA | DET0836 | DET1196 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | ATP-dependent DNA helicase PcrA; Identified by similarity to SP:P56255; match to protein family HMM TIGR01369. | 0.406 |
| guaA | ribBA | DET0836 | DET1188 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. | 0.701 |
| guaA | uvrA | DET0836 | DET0546 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Excinuclease ABC, A subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. | 0.424 |
| guaA | uvrB | DET0836 | DET0441 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Excinuclease ABC, B subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] | 0.546 |
| guaA | uvrC | DET0836 | DET1216 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Excinuclease ABC, C subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. | 0.637 |
| mutL | guaA | DET1195 | DET0836 | DNA mismatch repair protein, MutL/HexB family; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.422 |
| mutL | pcrA | DET1195 | DET1196 | DNA mismatch repair protein, MutL/HexB family; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | ATP-dependent DNA helicase PcrA; Identified by similarity to SP:P56255; match to protein family HMM TIGR01369. | 0.950 |
| mutL | uvrA | DET1195 | DET0546 | DNA mismatch repair protein, MutL/HexB family; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | Excinuclease ABC, A subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. | 0.546 |
| mutL | uvrB | DET1195 | DET0441 | DNA mismatch repair protein, MutL/HexB family; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | Excinuclease ABC, B subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] | 0.548 |
| mutL | uvrC | DET1195 | DET1216 | DNA mismatch repair protein, MutL/HexB family; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | Excinuclease ABC, C subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. | 0.655 |
| mutM | guaA | DET1389 | DET0836 | formamidopyrimidine-DNA glycosylase; Identified by match to protein family HMM PF01149; match to protein family HMM TIGR00577. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.419 |
| mutM | uvrC | DET1389 | DET1216 | formamidopyrimidine-DNA glycosylase; Identified by match to protein family HMM PF01149; match to protein family HMM TIGR00577. | Excinuclease ABC, C subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. | 0.668 |
| nuoH | uvrC | DET0927 | DET1216 | Proton-translocating NADH-quinone oxidoreductase, H subunit; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone. | Excinuclease ABC, C subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. | 0.588 |