STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DET1321Acetyltransferase, GNAT family; Identified by similarity to GP:29897287. (267 aa)    
Predicted Functional Partners:
ilvN
Acetolactate synthase, small subunit; Identified by match to protein family HMM TIGR00119.
  
 
 0.972
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
  
  
 0.743
ilvD
Dihydroxy-acid dehydratase; Identified by similarity to SP:P51785; match to protein family HMM TIGR00110; Belongs to the IlvD/Edd family.
  
  
 0.707
DET1320
Conserved hypothetical protein; Identified by similarity to OMNI:NTL01BH0316.
 
     0.662
DET0521
Conserved hypothetical protein; Identified by similarity to OMNI:NTL01OI0672.
    
 0.645
DET0522
Conserved hypothetical protein; Identified by similarity to OMNI:NTL01ML1916.
    
 0.645
ilvE
Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
  
 
 0.603
DET0600
Soluble hydrogenase, tritium exchange subunit; Identified by similarity to SP:P16421.
  
 
 0.564
tyrA
Chorismate mutase/prephenate dehydratase.
  
  
 0.488
DET1322
Hypothetical protein; Identified by Glimmer2; putative.
       0.479
Your Current Organism:
Dehalococcoides mccartyi
NCBI taxonomy Id: 243164
Other names: D. mccartyi 195, Dehalococcoides ethenogenes 195, Dehalococcoides mccartyi 195, Dehalococcoides mccartyi str. 195, Dehalococcoides mccartyi strain 195
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