STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DET16056-pyruvoyl tetrahydrobiopterin synthase, putative. (123 aa)    
Predicted Functional Partners:
folE
GTP cyclohydrolase I; Identified by similarity to SP:P19465; match to protein family HMM PF01227; match to protein family HMM TIGR00063.
  
 
 0.992
DET0299
Transcriptional regulator, Crp/Fnr family; Identified by match to protein family HMM PF00027.
    
  0.927
DET0736
Oxidoreductase, short chain dehydrogenase/reductase family; Identified by similarity to SP:P37769.
    
 0.830
fabG
3-oxoacyl-acyl carrier protein reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family.
    
 0.830
folK
2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; Identified by match to protein family HMM TIGR01498.
     
 0.818
folP
Dihydropteroate synthase; Identified by similarity to SP:P28822; match to protein family HMM TIGR01496.
     
 0.810
cysS
cysteinyl-tRNA synthetase; Identified by match to protein family HMM TIGR00435; Belongs to the class-I aminoacyl-tRNA synthetase family.
   
  
 0.587
guaA
GMP synthase; Catalyzes the synthesis of GMP from XMP.
     
 0.531
recA
RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
       0.498
tatA
Twin-arginine translocation protein, TatA/E family; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
       0.458
Your Current Organism:
Dehalococcoides mccartyi
NCBI taxonomy Id: 243164
Other names: D. mccartyi 195, Dehalococcoides ethenogenes 195, Dehalococcoides mccartyi 195, Dehalococcoides mccartyi str. 195, Dehalococcoides mccartyi strain 195
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.