STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DET1632Identified by match to protein family HMM PF01106. (72 aa)    
Predicted Functional Partners:
DET0248
Cysteine desulfurase; Identified by similarity to SP:O54055.
  
 
 0.750
DET0951
nifU domain protein; Identified by similarity to SP:P05340; match to protein family HMM PF01592.
  
 
 0.712
ilvD
Dihydroxy-acid dehydratase; Identified by similarity to SP:P51785; match to protein family HMM TIGR00110; Belongs to the IlvD/Edd family.
  
 
 0.672
DET0123
Pyridine nucleotide-disulphide oxidoreductase family protein.
   
  
 0.640
DET1631
TPR domain protein; Identified by match to protein family HMM PF00515.
     
 0.543
gyrA
DNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
       0.484
DET0088
Reductive dehalogenase domain protein; Identified by similarity to GP:8163916.
   
    0.465
DET0191
Iron-sulfur cluster-binding protein.
   
    0.465
DET0235
Reductive dehalogenase, putative; Identified by similarity to GP:8163916; match to protein family HMM TIGR01409.
   
    0.465
DET0868
Hydrogenase, EchF subunit, putative; Identified by similarity to GP:3005972.
   
    0.465
Your Current Organism:
Dehalococcoides mccartyi
NCBI taxonomy Id: 243164
Other names: D. mccartyi 195, Dehalococcoides ethenogenes 195, Dehalococcoides mccartyi 195, Dehalococcoides mccartyi str. 195, Dehalococcoides mccartyi strain 195
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