Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
purBAdenylosuccinate lyase; Similar to GB:J02732 SP:P12047 PID:143366 GB:AL009126 percent identity: 72.62; identified by sequence similarity; putative. (435 aa)    
Predicted Functional Partners:
purA
Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
 
 0.999
purC
Phosphoribosylaminoimidazole-succinocarboxamide synthase; Similar to GB:J02732 SP:P12046 PID:143367 GB:AL009126 percent identity: 71.37; identified by sequence similarity; putative; Belongs to the SAICAR synthetase family.
 
 0.999
purF
Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
  
 
 0.995
purH
Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Similar to GB:J02732 SP:P12048 PID:143373 GB:AL009126 percent identity: 66.73; identified by sequence similarity; putative.
  
 0.994
purM
Phosphoribosylformylglycinamidine cyclo-ligase; Similar to GB:J02732 SP:P12043 PID:143371 GB:AL009126 percent identity: 63.01; identified by sequence similarity; putative.
  
 
 0.991
purE
Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).
  
 
 0.990
purK
Phosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
  
 
 0.990
purD
Phosphoribosylamine--glycine ligase; Similar to SP:P15640 GB:J05126 GB:X51950 PID:147421 PID:396344 percent identity: 62.95; identified by sequence similarity; putative.
  
 
 0.985
gmk
Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.
 
 
 0.956
DR_0878
Adenine phosphoribosyltransferase, putative; Similar to GB:L77117 SP:Q59049 PID:1592237 percent identity: 53.60; identified by sequence similarity; putative.
  
 0.949
Your Current Organism:
Deinococcus radiodurans
NCBI taxonomy Id: 243230
Other names: D. radiodurans R1, Deinococcus radiodurans R1, Deinococcus radiodurans str. R1
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