STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (272 aa)    
Predicted Functional Partners:
guaA
GMP synthase; Catalyzes the synthesis of GMP from XMP.
 
 
 0.966
DR_0878
Adenine phosphoribosyltransferase, putative; Similar to GB:L77117 SP:Q59049 PID:1592237 percent identity: 53.60; identified by sequence similarity; putative.
  
 
 0.930
xpt
Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.
  
 
 0.930
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
   
 0.922
DR_1376
Hypoxanthine-guanine phosphoribosyltransferase; Similar to GB:D26185 SP:P37472 PID:467457 GB:AL009126 percent identity: 69.14; identified by sequence similarity; putative; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
  
  
 0.919
DR_1838
GTP pyrophosphokinase; Similar to GB:X72832 SP:Q54089 percent identity: 62.15; identified by sequence similarity; putative.
  
 
 0.915
DR_2635
Pyruvate kinase; Similar to PID:598097 SP:Q46078 percent identity: 63.38; identified by sequence similarity; putative; Belongs to the pyruvate kinase family.
  
 
 0.912
surE
Survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
  
  
  0.911
DR_2374
Ribonucleoside-diphosphate reductase-related protein; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
    
 0.908
DR_0505
5`-nucleotidase family protein; Similar to PID:1239994 SP:P54602 GB:AL009126 percent identity: 53.23; identified by sequence similarity; putative; Belongs to the 5'-nucleotidase family.
    
  0.900
Your Current Organism:
Deinococcus radiodurans
NCBI taxonomy Id: 243230
Other names: D. radiodurans R1, Deinococcus radiodurans R1, Deinococcus radiodurans str. R1
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.