Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (272 aa)    
Predicted Functional Partners:
guaA
GMP synthase; Catalyzes the synthesis of GMP from XMP.
 
 
 0.970
purB
Adenylosuccinate lyase; Similar to GB:J02732 SP:P12047 PID:143366 GB:AL009126 percent identity: 72.62; identified by sequence similarity; putative.
 
 
 0.956
xpt
Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.
  
 
 0.932
DR_1376
Hypoxanthine-guanine phosphoribosyltransferase; Similar to GB:D26185 SP:P37472 PID:467457 GB:AL009126 percent identity: 69.14; identified by sequence similarity; putative; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
  
 
 0.920
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
   
 0.918
DR_1838
GTP pyrophosphokinase; Similar to GB:X72832 SP:Q54089 percent identity: 62.15; identified by sequence similarity; putative.
  
 
 0.916
surE
Survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
  
  
  0.911
DR_2374
Ribonucleoside-diphosphate reductase-related protein; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
    
 0.906
DR_0505
5`-nucleotidase family protein; Similar to PID:1239994 SP:P54602 GB:AL009126 percent identity: 53.23; identified by sequence similarity; putative; Belongs to the 5'-nucleotidase family.
    
  0.900
prs
Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
 
  
 0.891
Your Current Organism:
Deinococcus radiodurans
NCBI taxonomy Id: 243230
Other names: D. radiodurans R1, Deinococcus radiodurans R1, Deinococcus radiodurans str. R1
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