node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GSU0485 | folE | GSU0485 | GSU0484 | Protein of unknown function DUF2064. | GTP cyclohydrolase I; Converts GTP to 7,8-dihydroneopterin triphosphate. | 0.700 |
GSU0485 | queC | GSU0485 | GSU0483 | Protein of unknown function DUF2064. | 7-cyano-7-deazaguanine synthase; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | 0.512 |
GSU1821 | folE | GSU1821 | GSU0484 | N-acetylmuramyl-L-alanine amidase. | GTP cyclohydrolase I; Converts GTP to 7,8-dihydroneopterin triphosphate. | 0.648 |
folE | GSU0485 | GSU0484 | GSU0485 | GTP cyclohydrolase I; Converts GTP to 7,8-dihydroneopterin triphosphate. | Protein of unknown function DUF2064. | 0.700 |
folE | GSU1821 | GSU0484 | GSU1821 | GTP cyclohydrolase I; Converts GTP to 7,8-dihydroneopterin triphosphate. | N-acetylmuramyl-L-alanine amidase. | 0.648 |
folE | folK | GSU0484 | GSU2979 | GTP cyclohydrolase I; Converts GTP to 7,8-dihydroneopterin triphosphate. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase. | 0.877 |
folE | moaA | GSU0484 | GSU3146 | GTP cyclohydrolase I; Converts GTP to 7,8-dihydroneopterin triphosphate. | Pyranopterin triphosphate synthase; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. | 0.900 |
folE | ndk | GSU0484 | GSU1110 | GTP cyclohydrolase I; Converts GTP to 7,8-dihydroneopterin triphosphate. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.800 |
folE | pyk | GSU0484 | GSU3331 | GTP cyclohydrolase I; Converts GTP to 7,8-dihydroneopterin triphosphate. | Pyruvate kinase; Belongs to the pyruvate kinase family. | 0.817 |
folE | queC | GSU0484 | GSU0483 | GTP cyclohydrolase I; Converts GTP to 7,8-dihydroneopterin triphosphate. | 7-cyano-7-deazaguanine synthase; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | 0.667 |
folE | queD | GSU0484 | GSU1720 | GTP cyclohydrolase I; Converts GTP to 7,8-dihydroneopterin triphosphate. | 6-carboxy-5,6,7,8-tetrahydropterin synthase. | 0.939 |
folE | relA | GSU0484 | GSU2236 | GTP cyclohydrolase I; Converts GTP to 7,8-dihydroneopterin triphosphate. | GTP/GDP 3'-pyrophosphokinase and (p)ppGpp 3'-pyrophosphohydrolase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | 0.800 |
folE | ribA | GSU0484 | GSU1690 | GTP cyclohydrolase I; Converts GTP to 7,8-dihydroneopterin triphosphate. | 3,4-dihydroxy-2-butanone-4-phosphate synthase and GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. | 0.912 |
folK | folE | GSU2979 | GSU0484 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase. | GTP cyclohydrolase I; Converts GTP to 7,8-dihydroneopterin triphosphate. | 0.877 |
folK | ribA | GSU2979 | GSU1690 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase. | 3,4-dihydroxy-2-butanone-4-phosphate synthase and GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. | 0.579 |
moaA | folE | GSU3146 | GSU0484 | Pyranopterin triphosphate synthase; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. | GTP cyclohydrolase I; Converts GTP to 7,8-dihydroneopterin triphosphate. | 0.900 |
moaA | ndk | GSU3146 | GSU1110 | Pyranopterin triphosphate synthase; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.800 |
moaA | pyk | GSU3146 | GSU3331 | Pyranopterin triphosphate synthase; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. | Pyruvate kinase; Belongs to the pyruvate kinase family. | 0.800 |
moaA | relA | GSU3146 | GSU2236 | Pyranopterin triphosphate synthase; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. | GTP/GDP 3'-pyrophosphokinase and (p)ppGpp 3'-pyrophosphohydrolase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | 0.808 |
moaA | ribA | GSU3146 | GSU1690 | Pyranopterin triphosphate synthase; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. | 3,4-dihydroxy-2-butanone-4-phosphate synthase and GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. | 0.905 |