| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| glyA | ilvB | GSU1607 | GSU1911 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Acetolactate synthase, large subunit, biosynthetic type. | 0.468 |
| glyA | leuB | GSU1607 | GSU2879 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 3-isopropylmalate/3-methylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily. | 0.597 |
| glyA | ltaA | GSU1607 | GSU3162 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | L-allo-threonine aldolase, stereospecific. | 0.938 |
| glyA | tdcB | GSU1607 | GSU0486 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Threonine and serine dehydratase and deaminase, catabolic; Catalyzes the conversion of threonine to 2-oxobutanoate and ammonia. Functions in the threonine-dependent pathway of isoleucine biosynthesis, which is the minor pathway for isoleucine biosynthesis in G.sulfurreducens. Also displays serine ammonia-lyase activity, yielding pyruvate from L-serine; Belongs to the serine/threonine dehydratase family. | 0.950 |
| glyA | thrC | GSU1607 | GSU1695 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Threonine synthase. | 0.597 |
| glyA | trpA | GSU1607 | GSU2371 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.934 |
| glyA | trpB1 | GSU1607 | GSU2375 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.928 |
| ilvB | glyA | GSU1911 | GSU1607 | Acetolactate synthase, large subunit, biosynthetic type. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.468 |
| ilvB | ilvD | GSU1911 | GSU1912 | Acetolactate synthase, large subunit, biosynthetic type. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.995 |
| ilvB | ilvE | GSU1911 | GSU0656 | Acetolactate synthase, large subunit, biosynthetic type. | Branched-chain amino acid aminotransferase. | 0.722 |
| ilvB | ilvN | GSU1911 | GSU1910 | Acetolactate synthase, large subunit, biosynthetic type. | Acetolactate synthase, small subunit. | 0.999 |
| ilvB | leuB | GSU1911 | GSU2879 | Acetolactate synthase, large subunit, biosynthetic type. | 3-isopropylmalate/3-methylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily. | 0.994 |
| ilvB | tdcB | GSU1911 | GSU0486 | Acetolactate synthase, large subunit, biosynthetic type. | Threonine and serine dehydratase and deaminase, catabolic; Catalyzes the conversion of threonine to 2-oxobutanoate and ammonia. Functions in the threonine-dependent pathway of isoleucine biosynthesis, which is the minor pathway for isoleucine biosynthesis in G.sulfurreducens. Also displays serine ammonia-lyase activity, yielding pyruvate from L-serine; Belongs to the serine/threonine dehydratase family. | 0.983 |
| ilvB | thrC | GSU1911 | GSU1695 | Acetolactate synthase, large subunit, biosynthetic type. | Threonine synthase. | 0.647 |
| ilvD | ilvB | GSU1912 | GSU1911 | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | Acetolactate synthase, large subunit, biosynthetic type. | 0.995 |
| ilvD | ilvE | GSU1912 | GSU0656 | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | Branched-chain amino acid aminotransferase. | 0.986 |
| ilvD | ilvN | GSU1912 | GSU1910 | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | Acetolactate synthase, small subunit. | 0.985 |
| ilvD | leuB | GSU1912 | GSU2879 | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 3-isopropylmalate/3-methylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily. | 0.930 |
| ilvD | tdcB | GSU1912 | GSU0486 | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | Threonine and serine dehydratase and deaminase, catabolic; Catalyzes the conversion of threonine to 2-oxobutanoate and ammonia. Functions in the threonine-dependent pathway of isoleucine biosynthesis, which is the minor pathway for isoleucine biosynthesis in G.sulfurreducens. Also displays serine ammonia-lyase activity, yielding pyruvate from L-serine; Belongs to the serine/threonine dehydratase family. | 0.921 |
| ilvD | thrC | GSU1912 | GSU1695 | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | Threonine synthase. | 0.599 |
