Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
GSU2385Protein of unknown function DUF1638. (201 aa)    
Predicted Functional Partners:
GSU2386
UroD-like decarboxylase/methyltransferase, putative; Belongs to the uroporphyrinogen decarboxylase family.
    0.978
GSU2387
Corrinoid-binding domain protein.
 
    0.926
GSU2384
Sensor histidine kinase, GAF domain-containing; Domains: GAF, HisKA, HATPase_c.
       0.773
GSU2388
Sensor histidine kinase, HAMP and PAS domain-containing; Domains: HAMP, PAS, HisKA, HATPase_c.
  
    0.773
GSU2389
ABC transporter, periplasmic substrate-binding lipoprotein, putative.
  
    0.773
trpG
Anthranilate synthase, glutamine amidotransferase subunit.
       0.541
trpE
Anthranilate synthase, catalytic subunit; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high c [...]
       0.541
GSU1333
Hypothetical protein.
  
    0.496
htpG
Heat shock protein Hsp90; Molecular chaperone. Has ATPase activity.
       0.472
coxD
Cytochrome c oxidase, coo3-type, subunit IV.
  
    0.465
Your Current Organism:
Geobacter sulfurreducens
NCBI taxonomy Id: 243231
Other names: G. sulfurreducens PCA, Geobacter sulfurreducens PCA, Geobacter sulfurreducens str. PCA, Geobacter sulfurreducens strain PCA
Server load: low (14%) [HD]