Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
trm4Proliferating-cell nucleolar antigen, FMU/NOL1/NOP2 family; Catalyzes AdoMet-dependent formation of m5C in tRNA. Cytidine residue at either position 40 or position 48 is likely to be methylated; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (274 aa)    
Predicted Functional Partners:
MJ_1410
Conserved hypothetical protein; Similar to GB:AE000782 percent identity: 36.08; identified by sequence similarity; putative; Belongs to the UPF0113 family.
  
 
 0.970
MJ_1464
Hypothetical GTP-binding protein (SP:P40010); Similar to SP:P40010 PID:603598 percent identity: 34.59; identified by sequence similarity; putative; Belongs to the TRAFAC class YlqF/YawG GTPase family.
 
 
 0.919
MJ_1408
GTP-binding protein, member of GTP1/OBG-family; Similar to PID:1151233 percent identity: 30.46; identified by sequence similarity; putative; Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.
  
 
 0.917
MJ_0694
Conserved hypothetical protein; Similar to SP:Q12499 PID:1420682 PID:940841 percent identity: 43.15; identified by sequence similarity; putative.
  
 
 0.916
rlmE
Cell division protein FtsJ; Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
 
 
 0.916
thiL
Thiamine monphosphate kinase (thiL); Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family.
  
    0.893
rpl10
LSU ribosomal protein L10E; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family.
 
 
 0.882
rps8e
SSU ribosomal protein S8E; Similar to SP:P49402 percent identity: 50.00; identified by sequence similarity; putative.
  
 
 0.874
MJ_0024
Conserved hypothetical protein; Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently (By similarity).
     
 0.867
rpl30
LSU ribosomal protein L30P (rpmD); Similar to SP:P14035 PID:44769 percent identity: 71.43; identified by sequence similarity; putative.
  
 
 0.864
Your Current Organism:
Methanocaldococcus jannaschii
NCBI taxonomy Id: 243232
Other names: M. jannaschii DSM 2661, Methanocaldococcus jannaschii DSM 2661, Methanocaldococcus jannaschii str. DSM 2661, Methanococcus jannaschii DSM 2661
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