STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pus10Conserved hypothetical protein; Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs. (454 aa)    
Predicted Functional Partners:
trmY
Conserved hypothetical protein; Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs; Belongs to the methyltransferase superfamily. TrmY family.
 
   
 0.972
rpl21e
LSU ribosomal protein L21E; Similar to GP:1215982 percent identity: 39.73; identified by sequence similarity; putative; Belongs to the eukaryotic ribosomal protein eL21 family.
 
   
 0.934
truB
Centromere/microtubule-binding protein (cbf5); Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
   
  
 0.931
truA
Pseudouridylate synthase I (truA); Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs; Belongs to the tRNA pseudouridine synthase TruA family.
  
  
 0.903
trm1
N2,N2-dimethylguanosine tRNA methyltransferase (trm1); Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups; Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
 
   
 0.897
MJ_0039
Conserved hypothetical protein; Similar to GB:AE000666 percent identity: 44.44; identified by sequence similarity; putative.
     
 0.878
MJ_0038
Conserved hypothetical protein; Similar to GB:AE000666 percent identity: 51.12; identified by sequence similarity; putative.
 
   
 0.838
trm14
Conserved hypothetical protein; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the methylation of the guanosine nucleotide at position 6 (m2G6) in tRNA(Cys).
     
 0.730
MJ_0042
Hypothetical protein; Identified by GeneMark; putative; M. jannaschii predicted coding region MJ0042.
       0.642
thiI
Conserved hypothetical protein; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
     
 0.625
Your Current Organism:
Methanocaldococcus jannaschii
NCBI taxonomy Id: 243232
Other names: M. jannaschii DSM 2661, Methanocaldococcus jannaschii DSM 2661, Methanocaldococcus jannaschii str. DSM 2661, Methanococcus jannaschii DSM 2661
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