Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
MJ_0092Heterodisulfide reductase, subunit D (hdrD); Similar to GP:1890198 percent identity: 31.87; identified by sequence similarity; putative; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (489 aa)    
Predicted Functional Partners:
MJ_0033
Succinate dehydrogenase, flavoprotein subunit (sdhA); Similar to GP:1524302 percent identity: 41.63; identified by sequence similarity; putative.
 
  
 0.997
sucD
succinyl-CoA synthetase, alpha subunit (sucD); Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
 
  
 0.962
MJ_0091
Na+/Ca+ exchanger protein, putative; Similar to SP:P45394 PID:606134 GB:U00096 PID:1789587 percent identity: 31.58; identified by sequence similarity; putative.
       0.953
sucC
succinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
 
 
 0.947
MJ_0617
Tartrate dehydratse, subunit beta (ttdB); Similar to PID:882585 GB:U00096 PID:1789443 percent identity: 42.70; identified by sequence similarity; putative; Belongs to the class-I fumarase family.
    
 0.923
MJ_1294
Tartrate dehydratase, subunit alpha (ttdA); Similar to GB:L14781 SP:P05847 PID:347084 PID:882584 PID:1789442 percent identity: 32.86; identified by sequence similarity; putative.
    
 0.919
trmJ
Conserved hypothetical protein; Catalyzes the formation of 2'O-methylated cytidine (Cm32) at position 32 in tRNA; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
  
    0.806
vhuD
vhuD protein; Similar to GB:X61204 PID:44797 percent identity: 77.78; identified by sequence similarity; putative; Belongs to the MvhD/VhuD family.
     
 0.777
fdhB
Formate dehydrogenase, beta subunit; Catalyzes the oxidation of formate; Belongs to the FrhB family.
 
   
 0.752
purM
Phosphoribosylformylglycinamidine cyclo-ligase (purM); Similar to GB:J02732 SP:P12043 PID:143371 GB:AL009126 percent identity: 39.76; identified by sequence similarity; putative.
     
 0.750
Your Current Organism:
Methanocaldococcus jannaschii
NCBI taxonomy Id: 243232
Other names: M. jannaschii DSM 2661, Methanocaldococcus jannaschii DSM 2661, Methanocaldococcus jannaschii str. DSM 2661, Methanococcus jannaschii DSM 2661
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