STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MJ_0132Type I restriction-modification enzyme 2, M subunit; Similar to GB:L25415 PID:496158 percent identity: 39.36; identified by sequence similarity; putative; Belongs to the N4/N6-methyltransferase family. (220 aa)    
Predicted Functional Partners:
MJ_0130
Type I restriction-modification enzyme 2, S subunit; The M and S subunits together form a methyltransferase (MTase) that methylates two adenine residues in complementary strands of a bipartite DNA recognition sequence. In the presence of the R subunit the complex can also act as an endonuclease, binding to the same target sequence but cutting the DNA some distance from this site. Whether the DNA is cut or modified depends on the methylation state of the target sequence. When the target site is unmodified, the DNA is cut. When the target site is hemimethylated, the complex acts as a mai [...]
 
 
 0.990
MJ_0124
Type I restriction-modification enzyme 2, R subunit; Similar to GB:L42023 PID:1007240 PID:1221415 PID:1205524 PID:1574743 percent identity: 32.31; identified by sequence similarity; putative; To M.jannaschii MJ1214.
 
 
 0.981
MJ_1214
Type I restriction-modification enzyme 1, R subunit; Similar to GB:L42023 PID:1007240 PID:1221415 PID:1205524 PID:1574743 percent identity: 27.55; identified by sequence similarity; putative.
 
 
 0.981
MJ_1218
Type I restriction-modification enzyme 1, S subunit; Identified by sequence similarity; putative.
 
 
 0.977
MJ_1531
Type I restriction-modification enzyme, S subunit, putative; Similar to GB:X17591 PID:40467 percent identity: 37.84; identified by sequence similarity; putative; To M.jannaschii MJ0130 and MJ1218.
 
 
 0.975
MJ_0131
Hypothetical protein; Identified by GeneMark; putative; M. jannaschii predicted coding region MJ0131.
       0.702
mjaIVMP
Modification methylase, type II R/M system; This methylase recognizes the double-stranded sequence GTNNAC, causes specific methylation on ? on both strands, and protects the DNA from cleavage by the MjaIV endonuclease.
  
  
 0.561
rqcH
Conserved hypothetical protein; Probably part of the ribosome quality control system (RQC). May mediate the addition of alanine residues (Ala tailing) to incompletely synthesized nascent chains from stalled ribosomes, leading to their degradation; Belongs to the NEMF family.
  
  
 0.553
Your Current Organism:
Methanocaldococcus jannaschii
NCBI taxonomy Id: 243232
Other names: M. jannaschii DSM 2661, Methanocaldococcus jannaschii DSM 2661, Methanocaldococcus jannaschii str. DSM 2661, Methanococcus jannaschii DSM 2661
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