STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
trmItRNA (adenine(57)-N(1)/adenine(58)-N(1))-methyltransferase TrmI; Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family (282 aa)    
Predicted Functional Partners:
rlmE
Ribosomal RNA large subunit methyltransferase E; Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
   
  
 0.915
MJ0594
Probable Brix domain-containing ribosomal biogenesis protein; Probably involved in the biogenesis of the ribosome
  
    0.894
trm1
tRNA (guanine(26)-N(2))-dimethyltransferase; Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups
  
 
 0.883
ksgA
Probable ribosomal RNA small subunit methyltransferase A; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits
  
  
 0.874
rnhB
Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA- DNA hybrids; Belongs to the RNase HII family
  
    0.871
trm4
tRNA (cytosine(48)-C(5))-methyltransferase; Catalyzes AdoMet-dependent formation of m5C in tRNA. Cytidine residue at either position 40 or position 48 is likely to be methylated; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family
  
 
 0.831
trm5b
tRNA (guanine(37)-N1)-methyltransferase Trm5b; Specifically methylates the N1 position of guanosine-37 in various tRNAs
 
 
 0.830
truB
Probable tRNA pseudouridine synthase B; Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs
   
  
 0.817
tgtA
tRNA-guanine(15) transglycosylase; Exchanges the guanine residue with 7-cyano-7- deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D- loop) of archaeal tRNAs. Can also utilize guanine as substrate
  
  
 0.815
trmJ
tRNA (cytidine-2'-O-)-methyltransferase TrmJ; Catalyzes the formation of 2'O-methylated cytidine (Cm32) at position 32 in tRNA; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
      
 0.806
Your Current Organism:
Methanocaldococcus jannaschii
NCBI taxonomy Id: 243232
Other names: M. jannaschii DSM 2661, Methanocaldococcus jannaschii, Methanocaldococcus jannaschii DSM 2661, Methanocaldococcus jannaschii DSM2661, Methanocaldococcus jannaschii str. DSM 2661, Methanococcus jannaschii DSM 2661
Server load: low (7%) [HD]