node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MJ_0140 | MJ_0141 | MJ_0140 | MJ_0141 | Conserved hypothetical protein; Involved in the archaeal biosynthesis of heme. Catalyzes the oxiation of precorrin-2 into sirohydroclorin (By similarity). Belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | Conserved hypothetical protein; Similar to GB:AE000782 percent identity: 36.84; identified by sequence similarity; putative; Belongs to the M.jannaschii MJ0126/MJ0128/MJ0141/MJ0435/MJ0604/MJ1215/MJ1217/MJ1305/MJ1379 family. | 0.778 |
MJ_0140 | MJ_0142 | MJ_0140 | MJ_0142 | Conserved hypothetical protein; Involved in the archaeal biosynthesis of heme. Catalyzes the oxiation of precorrin-2 into sirohydroclorin (By similarity). Belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | Conserved hypothetical protein; Similar to GB:AE000782 percent identity: 29.84; identified by sequence similarity; putative; Belongs to the UPF0332 family. | 0.800 |
MJ_0140 | MJ_1241 | MJ_0140 | MJ_1241 | Conserved hypothetical protein; Involved in the archaeal biosynthesis of heme. Catalyzes the oxiation of precorrin-2 into sirohydroclorin (By similarity). Belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | Hypothetical protein; Identified by GeneMark; putative; M. jannaschii predicted coding region MJ1241. | 0.835 |
MJ_0140 | MJ_1620 | MJ_0140 | MJ_1620 | Conserved hypothetical protein; Involved in the archaeal biosynthesis of heme. Catalyzes the oxiation of precorrin-2 into sirohydroclorin (By similarity). Belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | Conserved hypothetical protein; Similar to GP:1652230 percent identity: 27.52; identified by sequence similarity; putative. | 0.805 |
MJ_0140 | cbiL | MJ_0140 | MJ_0771 | Conserved hypothetical protein; Involved in the archaeal biosynthesis of heme. Catalyzes the oxiation of precorrin-2 into sirohydroclorin (By similarity). Belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | Cobalamin biosynthesis precorrin-2 methyltransferase (cbiL); Methylates cobalt-precorrin-2 at the C-20 position to produce cobalt-precorrin-3A in the anaerobic cobalamin biosynthesis pathway. | 0.967 |
MJ_0140 | cbiX | MJ_0140 | MJ_0970 | Conserved hypothetical protein; Involved in the archaeal biosynthesis of heme. Catalyzes the oxiation of precorrin-2 into sirohydroclorin (By similarity). Belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | Conserved hypothetical protein; Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni- sirohydrochlorin. | 0.990 |
MJ_0140 | cobA | MJ_0140 | MJ_0965 | Conserved hypothetical protein; Involved in the archaeal biosynthesis of heme. Catalyzes the oxiation of precorrin-2 into sirohydroclorin (By similarity). Belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | uroporphyrin-III C-methyltransferase (cobA); Catalyzes both methylations at C-2 and C-7 of uroporphyrinogen III leading to precorrin-1 and precorrin-2; their oxidative esterification gives respectively factor I octamethyl ester and sirohydrochlorin. | 0.993 |
MJ_0140 | cobS | MJ_0140 | MJ_1438 | Conserved hypothetical protein; Involved in the archaeal biosynthesis of heme. Catalyzes the oxiation of precorrin-2 into sirohydroclorin (By similarity). Belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | Cobalamin (5'-phosphate) synthase (cobS); Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.758 |
MJ_0140 | hemA | MJ_0140 | MJ_0143 | Conserved hypothetical protein; Involved in the archaeal biosynthesis of heme. Catalyzes the oxiation of precorrin-2 into sirohydroclorin (By similarity). Belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | glutamyl-tRNA reductase (hemA); Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.972 |
MJ_0140 | hemD | MJ_0140 | MJ_0994 | Conserved hypothetical protein; Involved in the archaeal biosynthesis of heme. Catalyzes the oxiation of precorrin-2 into sirohydroclorin (By similarity). Belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | Uroporphyrinogen III synthase (hemD); Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.808 |
MJ_0141 | MJ_0140 | MJ_0141 | MJ_0140 | Conserved hypothetical protein; Similar to GB:AE000782 percent identity: 36.84; identified by sequence similarity; putative; Belongs to the M.jannaschii MJ0126/MJ0128/MJ0141/MJ0435/MJ0604/MJ1215/MJ1217/MJ1305/MJ1379 family. | Conserved hypothetical protein; Involved in the archaeal biosynthesis of heme. Catalyzes the oxiation of precorrin-2 into sirohydroclorin (By similarity). Belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.778 |
MJ_0141 | MJ_0142 | MJ_0141 | MJ_0142 | Conserved hypothetical protein; Similar to GB:AE000782 percent identity: 36.84; identified by sequence similarity; putative; Belongs to the M.jannaschii MJ0126/MJ0128/MJ0141/MJ0435/MJ0604/MJ1215/MJ1217/MJ1305/MJ1379 family. | Conserved hypothetical protein; Similar to GB:AE000782 percent identity: 29.84; identified by sequence similarity; putative; Belongs to the UPF0332 family. | 0.936 |
MJ_0141 | hemA | MJ_0141 | MJ_0143 | Conserved hypothetical protein; Similar to GB:AE000782 percent identity: 36.84; identified by sequence similarity; putative; Belongs to the M.jannaschii MJ0126/MJ0128/MJ0141/MJ0435/MJ0604/MJ1215/MJ1217/MJ1305/MJ1379 family. | glutamyl-tRNA reductase (hemA); Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.775 |
MJ_0142 | MJ_0140 | MJ_0142 | MJ_0140 | Conserved hypothetical protein; Similar to GB:AE000782 percent identity: 29.84; identified by sequence similarity; putative; Belongs to the UPF0332 family. | Conserved hypothetical protein; Involved in the archaeal biosynthesis of heme. Catalyzes the oxiation of precorrin-2 into sirohydroclorin (By similarity). Belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.800 |
MJ_0142 | MJ_0141 | MJ_0142 | MJ_0141 | Conserved hypothetical protein; Similar to GB:AE000782 percent identity: 29.84; identified by sequence similarity; putative; Belongs to the UPF0332 family. | Conserved hypothetical protein; Similar to GB:AE000782 percent identity: 36.84; identified by sequence similarity; putative; Belongs to the M.jannaschii MJ0126/MJ0128/MJ0141/MJ0435/MJ0604/MJ1215/MJ1217/MJ1305/MJ1379 family. | 0.936 |
MJ_0142 | hemA | MJ_0142 | MJ_0143 | Conserved hypothetical protein; Similar to GB:AE000782 percent identity: 29.84; identified by sequence similarity; putative; Belongs to the UPF0332 family. | glutamyl-tRNA reductase (hemA); Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.773 |
MJ_1241 | MJ_0140 | MJ_1241 | MJ_0140 | Hypothetical protein; Identified by GeneMark; putative; M. jannaschii predicted coding region MJ1241. | Conserved hypothetical protein; Involved in the archaeal biosynthesis of heme. Catalyzes the oxiation of precorrin-2 into sirohydroclorin (By similarity). Belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.835 |
MJ_1241 | cbiX | MJ_1241 | MJ_0970 | Hypothetical protein; Identified by GeneMark; putative; M. jannaschii predicted coding region MJ1241. | Conserved hypothetical protein; Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni- sirohydrochlorin. | 0.659 |
MJ_1241 | cobA | MJ_1241 | MJ_0965 | Hypothetical protein; Identified by GeneMark; putative; M. jannaschii predicted coding region MJ1241. | uroporphyrin-III C-methyltransferase (cobA); Catalyzes both methylations at C-2 and C-7 of uroporphyrinogen III leading to precorrin-1 and precorrin-2; their oxidative esterification gives respectively factor I octamethyl ester and sirohydrochlorin. | 0.917 |
MJ_1620 | MJ_0140 | MJ_1620 | MJ_0140 | Conserved hypothetical protein; Similar to GP:1652230 percent identity: 27.52; identified by sequence similarity; putative. | Conserved hypothetical protein; Involved in the archaeal biosynthesis of heme. Catalyzes the oxiation of precorrin-2 into sirohydroclorin (By similarity). Belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.805 |