STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MJ_0158Selenocystein synthase (selA); Similar to SP:P23328 GB:M64177 PID:147804 PID:466729 GB:U00096 percent identity: 34.65; identified by sequence similarity; putative; Belongs to the UPF0425 family. (374 aa)    
Predicted Functional Partners:
MJ_0157
Hypothetical protein; Identified by GeneMark; putative; M. jannaschii predicted coding region MJ0157.
  
    0.988
serS
seryl-tRNA synthetase (serS); Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec).
    
 0.941
spcS
Conserved hypothetical protein; Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl- tRNA(Sec) required for selenoprotein biosynthesis.
     
 0.924
pstK
Yeast KTI12 Protein; Specifically phosphorylates seryl-tRNA(Sec) to O- phosphoseryl-tRNA(Sec), an activated intermediate for selenocysteine biosynthesis.
     
  0.900
trkA
TRK system potassium uptake protein (trkA); Part of a potassium transport system.
  
  
 0.822
MJ_0717
Molybdopterin converting factor, subunit 2 (moaE); Similar to GB:X70420 SP:P30749 PID:42012 GB:U00096 PID:1787003 percent identity: 31.52; identified by sequence similarity; putative; To Synechocystis PCC 6803 slr0903.
   
  
 0.505
aroA
Conserved hypothetical protein; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. Can also catalyze the cleavage of fructose-1,6- bisphosphate (FBP) to glyceraldehyde-3-phosphate (GAP) and dihydroxyacetone phosphate (DHAP).
   
    0.448
MJ_0531
Conserved hypothetical protein; Similar to SP:P42297 PID:603780 PID:849027 GB:AL009126 percent identity: 37.76; identified by sequence similarity; putative; Belongs to the universal stress protein A family.
  
 
 0.442
MJ_0990
Conserved hypothetical protein; Similar to GB:L13279 SP:P31065 PID:290415 GB:U00096 PID:1788239 percent identity: 39.13; identified by sequence similarity; putative; Belongs to the sulfur carrier protein TusA family.
  
  
 0.438
fdhD
Formate dehydrogenase (fdhD); Required for formate dehydrogenase (FDH) activity. Belongs to the FdhD family.
  
  
 0.432
Your Current Organism:
Methanocaldococcus jannaschii
NCBI taxonomy Id: 243232
Other names: M. jannaschii DSM 2661, Methanocaldococcus jannaschii DSM 2661, Methanocaldococcus jannaschii str. DSM 2661, Methanococcus jannaschii DSM 2661
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.